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The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Authors:Molloy Timothy J  Bosma Astrid J  Baumbusch Lars O  Synnestvedt Marit  Borgen Elin  Russnes Hege Giercksky  Schlichting Ellen  van't Veer Laura J  Naume Bjørn
Affiliation:(1) Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands;(2) Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953, Nydalen, 0424, Oslo, Norway;(3) Biomedical Research Group, Department of Informatics, University of Oslo, Postboks 4953, Nydalen, 0424, Oslo, Norway;(4) Division of Surgery and Cancer Medicine, Oslo University Hospital Radiumhospitalet, Postboks 4953, Nydalen, 0424, Oslo, Norway;(5) Department of Pathology, Oslo University Hospital Radiumhospitalet, Postboks 4953, Nydalen, 0424, Oslo, Norway;(6) Institute of Clinical Medicine, University of Oslo, Postboks 4953, Nydalen, 0424, Oslo, Norway
Abstract:

Introduction  

The detection of circulating tumour cells (CTCs) in the peripheral blood and disseminated tumour cells (DTCs) in the bone marrow are promising prognostic tools for risk stratification in early breast cancer. There is, however, a need for further validation of these techniques in larger patient cohorts with adequate follow-up periods.
Keywords:
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