结节性甲状腺肿与甲状腺癌关系的探讨

目的探讨结节性甲状腺肿与甲状腺癌之间的关系。方法对 5 0 8例结节性甲状腺肿 ,5 2例甲状腺癌的病理特点、癌前病变、二者之间的过渡及癌旁病变 ,进行分析研究。结果结节性甲状腺肿伴非典型增生为 6 .9% (35 / 5 0 8) ,其中轻度非典型增生占 6 .1% (31/ 5 0 8) ,重度非典型增生占 0 .8% (4 / 5 0 8)。结节性甲状腺肿伴癌变为 1.2 % (6 / 5 0 8)。甲状腺癌旁伴有结节性甲状腺肿病变者达 81% (4 2 / 5 2 )。结论结节性甲状腺肿是甲状腺癌的癌前疾病 ,其发生发展过程中可发生癌前病变 ,对伴有非典型性增生的病例应加强随访。

A study of the relationship between nodular goiter and thyroid carcinoma

Objective To explore the relationship between nodular goiter and thyroid carcinoma. Methods Five hundred and eight cases of nodular goiter and fifty-two cases of thyroid carcinoma were collected.Their pathological feature, precancerous change,transitional change between the two clinical entities and changes around carcinoma were observed and analyzed. Results Nodular goiters with atypical hyperplasia were 6.9%(35/508),among them slight atypical hyperplasias were 6.1%(31/508) and severe atypical hyperplasias were 0.8%(4/508).Nodular goiters with canceration change were 1.2%(6/508).Thyroid carcinomas with nodular goiter were 81%(42/52). Conclusions Nodular goiter is precancerous disease of thyroid carcinoma.Goiter cases with atypical hyperplasia should be closely followed up.