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| 肝细胞生长因子对急性心肌梗死后左室重构的预测作用 | |
| 引用本文： | 张莉,刘丰. 肝细胞生长因子对急性心肌梗死后左室重构的预测作用[J]. 心脏杂志, 2010, 22(2): 222-224 |
| 作者姓名： | 张莉 刘丰 |
| 作者单位： | 1.增城市人民医院心内科，广东 广州 511300；2.广州市第一人民医院老年科，广东 广州 510180 |
| 摘 要： | 目的: 探讨血清肝细胞生成因子(HGF)对急性心肌梗死(AMI)后早期左室重构的预测价值。方法: 36例AMI患者入院时及发病7 d测定血清HGF水平；AMI其中的26例分别于发病后7~10 d及发病后3个月行超声心动图检查，3个月时左室舒张末期容积指数（LVEDVI）与7~10 d时比增加≥5 ml/m2定义为左室重构组(n=11)，对两组血清HGF值进行比较。结果: AMI患者入院时血清HGF浓度较对照组明显升高［(809±288)ng/L vs.(620±162)ng/L，P<0.01］，7 d时升高更显著［(1 607±1 355)ng/L，P<0.01］。发病7 d时血清HGF浓度在左室重构组较非左室重构组升高［(2 216±1 522)ng/L vs.(1 176±593)ng/L，P<0.05］，而入院时两组浓度则无显著差异。结论: AMI时血清HGF浓度升高，AMI后7 d时增高的血清HGF可能预示心室重构。 |
| 关 键 词： | 心肌梗死，急性 肝细胞生长因子 左室重构 |
| 收稿时间： | 2008-12-31 |
Serum hepatocyte growth factor in predicting left ventricular remodeling after acute myocardial infarction |
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| ZHANG Li,LIU Feng. Serum hepatocyte growth factor in predicting left ventricular remodeling after acute myocardial infarction[J]. Chinese Heart Journal, 2010, 22(2): 222-224 | |
| Authors: | ZHANG Li LIU Feng |
| Affiliation: | ZHANG Li1,LIU Feng2(1.Department of Cardiology,Zengcheng People's Hospital,Guangzhou 511300,Guangdong,China,2.Department of Geriatrics,Guangzhou First Municipal Hospital,Guangzhou 510180,China) |
| Abstract: | AIM: To investigate the clinical significance of serum hepatocyte growth factor(HGF) in predicting left ventricular remodeling after acute myocardial infarction(AMI).METHODS: Venous blood samples were obtained at hospital admission and 7 days after in 36 patients with AMI and in 27 control subjects.Left ventricular end-diastolic volume index(LVEDVI) in the subacute(7-10 days) and chronic(3 months) phases was assessed in 26 patients with AMI.Left ventricular remodeling group(n=11) was defined as an increase ... |
| Keywords: | acute myocardial infarction hepatocyte growth factor left ventricular remodeling |
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