A群脑膜炎奈瑟氏菌脂多糖抗原血清学分型的流行病学意义

从江西等省收集了A群脑膜炎奈瑟氏菌324株,应用我们所报道的分型方法可以将96.91%的菌株分成三个主要的脂多糖血清型。不同地区所收集的A群菌株脂多糖血清型的地区分布是不同的,病人与其密切接触者的菌株具有相同的脂多糖血清型,L₁₀型菌株的致病力较强,可以引起流脑流行。本文所述的分型方法操作简便,分型率高。因此,作者认为A群菌株脂多糖血清学分型具有一定的流行病学意义,此分型方法很适于流行病学调查。

Epidemiological Significance of Lipopolysaccharide Serotyping in Neisseria Meningitidis Group A

324 strains of Neisseria meningitidis group A were collected from Jiangxi and other provinces in China. 96.9 per cent of them could be dividedinto three main lipopolysaccharide (LPS) serotypes with the serotyping method revised by us. Distribution of LPS serotypes was distinct among the group-A strains collected from various parts of China, and LPS serotypes of group-A strains from the patients'' close contacts seemed to be identical with those of patients. The strains of L10 serotype had higher pathogenicity and could cause the prevalence of epidemic cerebrospinal menigitis in China. The serotyping method described in this paper was simple and convenient to perform and it''s positive rate was very high. Therefore, the authors think that LPS serotyping of the group-A strains possesses a definite epidemiological significance and the technique of serotyping is suitable for epidemiological investigation.