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| 汽车尾气对小鼠骨髓细胞的致突变性 | |
| 引用本文： | 任长江,骆延,王宏伟. 汽车尾气对小鼠骨髓细胞的致突变性[J]. 环境与健康杂志, 2004, 21(5): 321-322 |
| 作者姓名： | 任长江 骆延 王宏伟 |
| 作者单位： | 河南科技大学医学院细胞遗传教研室,河南,洛阳,4710003;河南科技大学医学院细胞遗传教研室,河南,洛阳,4710003;河南科技大学医学院细胞遗传教研室,河南,洛阳,4710003 |
| 摘 要： | 目的探讨汽车尾气对小鼠骨髓细胞的致突变性。方法健康昆明种小鼠100只,随机分10组,雌雄各半。用汽车尾气分别染毒15、30、45、60d后,观察小鼠骨髓细胞微核率和姐妹染色单体交换率变化,并与正常饲养组小鼠骨髓细胞进行比较。结果各染毒组与对照组之间的微核率、姐妹染色单体交换率有差异,除15d组和对照组的差异无显著性(P>0.05)外,其他各组和对照组比较,差异均有显著性(P<0.01);且染毒时间对小鼠骨髓细胞的致突变影响呈正相关。结论汽车尾气对小鼠骨髓细胞有致突变性。 |
| 关 键 词： | 汽车尾气 突变 微核试验 姐妹染色单体交换 试验 |
| 文章编号： | 1001-5914(2004)05-0321-02 |
| 修稿时间： | 2003-12-25 |
Mouse Bone Marrow Cell Mutation Induced by Vechile Exhaust |
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| REN Chang,jiang,LUO Yan,WANG Hong,wei. Henan Medical University,Zhengzhou,Henan ,China. Mouse Bone Marrow Cell Mutation Induced by Vechile Exhaust[J]. Journal of Environment and Health, 2004, 21(5): 321-322 | |
| Authors: | REN Chang jiang LUO Yan WANG Hong wei. Henan Medical University Zhengzhou Henan China |
| Affiliation: | REN Chang,jiang,LUO Yan,WANG Hong,wei. Henan Medical University,Zhengzhou,Henan 471003,China |
| Abstract: | Objective To investigate the effects of the mouse bone marrow cell mutation induced by vechile exhaust. Methods The mice were divided into two groups. The experimental group exposed to car exhaust, after exposure of given days (15 d, 30 d, 45 d, 60 d), bone marrow micronucleus and SCE rates in the experimental group were compared with the control. Results Significant differences had been seen between the two groups in bone marrow micronucleus and SCE rates except the 15 d group. The rate of the bone marrow cell mutation was positively correlated to the periods of exposure to car exhaust. Conclusion Car exhaust has effect of mutation on mouse cells. |
| Keywords: | Vechile exhaust Mutation Micronucleus test Sister chromatid exchange test |
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