| 肺炎链球菌溶血素诱导THP-1细胞凋亡涉及MAPK1/3信号途径 |
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| 引用本文： | 姜慧,贺潇,袁军,王虹,李忱炜,董杰,崔瑾,董姗姗,周爱娥,张雪梅,胥文春,尹一兵,何於娟.肺炎链球菌溶血素诱导THP-1细胞凋亡涉及MAPK1/3信号途径[J].第三军医大学学报,2011,33(13):1338-1341. |
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| 作者姓名： | 姜慧 贺潇 袁军 王虹 李忱炜 董杰 崔瑾 董姗姗 周爱娥 张雪梅 胥文春 尹一兵 何於娟 |
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| 作者单位： | 重庆医科大学检验系临床检验诊断学教育部重点实验室,重庆,400016 |
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| 基金项目： | 国家自然科学基金面上项目(30872363)~~ |
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| 摘 要： | 目的 探讨肺炎链球菌溶血素(pneumolysin,Ply)对人急性单核细胞白血病单核细胞株THP-1细胞的增殖抑制和诱导凋亡作用及机制.方法 MTT法检测Ply对THP-1细胞的增殖抑制.瑞氏染色观察Ply对人THP-1细胞形态的影响.AnnexinV-FITC/PI双标法检测细胞凋亡.琼脂糖凝胶电泳观察凋亡细胞DN...
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| 关 键 词： | 肺炎链球菌溶血素 THP-1细胞 凋亡 MAPK1/3通路 |
Pneumolysin induces apoptosis in human THP-1 cells through MAPK1/3 signal pathway |
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| Jiang Hui,He Xiao,Yuan Jun,Wang Hong,Li Chenwei,Dong Jie,Cui Jin,Dong Shanshan,Zhou Ai'e,Zhang Xuemei,Xu Wenchun,Yin Yibing,He Yujuan.Pneumolysin induces apoptosis in human THP-1 cells through MAPK1/3 signal pathway[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(13):1338-1341. |
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| Authors: | Jiang Hui He Xiao Yuan Jun Wang Hong Li Chenwei Dong Jie Cui Jin Dong Shanshan Zhou Ai'e Zhang Xuemei Xu Wenchun Yin Yibing He Yujuan |
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| Institution: | Jiang Hui,He Xiao,Yuan Jun,Wang Hong,Li Chenwei,Dong Jie,Cui Jin,Dong Shanshan,Zhou Ai'e,Zhang Xuemei,Xu Wenchun,Yin Yibing,He Yujuan(Key Laboratory of Clinical Laboratory Diagnostics of Ministry of Education,Faculty of Laboratory Medicine,Chongqing Medical University,Chongqing,400016,China) |
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| Abstract: | |
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| Keywords: | pneumolysin THP-1 cells apoptosis MAPK1/3 signal pathway |
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