急性心肌梗死患者择期冠脉支架置入术对血清细胞色素C水平的影响

目的：探讨择期冠脉支架置入术对急性心肌梗死（Acute myocardial infarction,AMI）患者血清细胞色素C水平的影响。方法：选取2011-03～2012-05我院心内科收治的32例AMI患者,设定其为观察组;同时期以胸闷、心慌等临床症状在本院就诊,而经冠状动脉造影检查显示不是冠心病的32例患者为对照组。采用酶联免疫吸附（ELISA）方法测定观察组患者在冠状动脉支架置入术前,术后48h、72 h血清细胞色素C（Cyt C）浓度。结果：观察组冠状动脉支架置人术前血清Cyt C水平明显高于对照组（P〈0.05）,差异比较具有统计学意义;术后48h、72h血清Cyt C水平均明显低于术前（P〈0.05）,差异比较具有统计学意义;而观察组术后48h、72h血清Cyt C水平较对照组无明显差异（P〉0.05）。结论：择期冠脉支架置入术可明显降低AMI患者心肌细胞凋亡的程度及死亡率。

PATIENTS ACUTE MYOCARDIAL INFARCTION UNDERGOING ELECTIVE CORONARY ARTERY CAROTID STENTING EFFECTS ON SERUM LEVEL OF CYTOCHROME C

Objective： Explore elective coronary artery carotid stenting for acute myocardial infarction（acute myocardial infarction,AMI） patients with serum level of cytochrome C.Methods： Selec of 32 patients with AMI admitted in department of cardiology in March 2011 ～ May 2012,and set it as observation group;at the same time to bosom frowsty,flustered,and other clinical symptoms treated in our hospital,but the coronary angiography examination showed the 32 patients of coronary heart disease as control group.Using enzyme-linked immunosorbent（ELISA） method for determination of observation group patients before coronary artery carotid stenting,48 h,72 h after the serum concentration of cytochrome C（Cyt C）.Results： Observation group patients who were preoperative coronary stenting showed Cyt C serum level significantly higher than the control group（P 0.05）,the difference is statistically significant;after 48 h,72 h Cyt C levels of serum were significantly lower than before operation（P 0.05）,the difference is statistically significant;And the observation group after 48 h,72 h serum Cyt C level than the control group and had no significant difference（P 0.05）.Conclusion： Elective coronary artery carotid stenting can obviously reduce the degree and the mortality of AMI patients with myocardial cell apoptosis.