| 满山红总黄酮固体分散体的制备工艺考察 |
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| 引用本文： | 孔艳,李开,苏建春,赵俊霞,张立,尹蓉莉.满山红总黄酮固体分散体的制备工艺考察[J].中国实验方剂学杂志,2013,19(20):24-26. |
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| 作者姓名： | 孔艳 李开 苏建春 赵俊霞 张立 尹蓉莉 |
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| 作者单位： | 成都中医药大学, 成都 611137;成都中医药大学, 成都 611137;成都中医药大学, 成都 611137;成都中医药大学, 成都 611137;成都中医药大学, 成都 611137;成都中医药大学, 成都 611137 |
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| 摘 要： | 目的: 优选满山红总黄酮固体分散体的制备工艺。方法: 分别以聚乙二醇6000(PEG6000),聚乙烯吡咯烷酮K30(PVPK30),泊洛沙姆188(Pluronic F68)为载体,采用适合载体的熔融-溶剂法和溶剂法制备满山红总黄酮-载体不同比例(1:1,1:2,1:4,1:6)的固体分散体。以满山红总黄酮为检测指标,通过UV测定体外溶出度,计算各固体分散体的Td值。结果: 最佳制备工艺为以4倍量PVPK30为载体,加20倍量无水乙醇溶解,于50℃旋蒸除去无水乙醇,满山红总黄酮的体外溶出率达100%。PEG6000为载体时,不同比例的固体分散体Td分别为6.329,5.225,0.096,4.755 min;Pluronic F68为载体时,各固体分散体Td分别为4.045,3.561,0.018,0.026 min;PVPK30为载体时,各固体分散体Td分别为5.000,5.000,0.005,0.056 min。结论: 溶剂法可用于制备满山红总黄酮固体分散体,具有很好的增溶效果,但不适合工业生产。
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| 关 键 词： | 满山红总黄酮 固体分散体 体外溶出 溶剂法 熔融法 |
| 收稿时间： | 2013/3/21 0:00:00 |
Investigation of Preparation Technology of Rhododendri Daurici Folium Total Flavonoids Solid Dispersions |
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| KONG Yan,LI Kai,SU Jian-chun,ZHAO Jun-xi,ZHANG Li and YIN Rong-li.Investigation of Preparation Technology of Rhododendri Daurici Folium Total Flavonoids Solid Dispersions[J].China Journal of Experimental Traditional Medical Formulae,2013,19(20):24-26. |
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| Authors: | KONG Yan LI Kai SU Jian-chun ZHAO Jun-xi ZHANG Li and YIN Rong-li |
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| Institution: | Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
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| Abstract: | |
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| Keywords: | total flavonoids from Rhododendri Daurici Folium solid dispersions in vitro dissolution solvent method melting method |
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