髓鞘碱性蛋白和白细胞介素16在多发性硬化发病机制和临床中的探讨

目的探讨髓鞘碱性蛋白(MBP)和白细胞介素16(IL-16)在多发性硬化(MS)发病过程中的水平变化和临床意义。方法用ELISA法检测MS组(CSF31例、Serum32例)、Guillain-Barre综合征(GBS)组(CSF和Serum均为24例)和对照组(CSF24例、Serum28例)中MBP和IL-16的水平。结果MS组中CSF和Serum中MBP水平均显著高于GBS及对照组(P<0.01),CSFIL-16的水平显著高于对照组(P<0.01),但SerumIL-16水平和对照组相比无明显差异性。MS组CSF中MBP的水平和IL-16的水平显著相关(r=0.463,P<0.05),但Serum中两者间无相关性。结论MBP对MS的发病有很高的敏感性,IL-16主要在中枢神经系统局部产生并参与MS的炎症过程。

Investigation of Myelin Basic Protein and IL-16 in Patients with Multiple Sclerosis

Objective To determine the levels and significance of myelin basic protein (MBP) and interleukin 16(IL-16) in patients with multiple sclerosis (MS). Method The levels of MBP and IL-16 were measured in patients with MS (CSF 31 cases; serum 32 cases), Guillain-Barre syndrome (GBS; CSF 24 cases, serum 24 cases) and in control subjects(CSF 24 cases; serum 28 cases) by ELISA method. Result The levels of MBP in CSF and serum were increased significantly in MS patients compared with those in GBS or control subjects (P < 0.01). Levels of IL-16 in CSF also increased significantly in MS patients compared with the control subjects(P < 0.01), but no difference was found in serum between MS and control subjects. The concentration of MBP in CSF correlated with the level of IL-16 in CSF (r=0.463, P < 0.05), but no correlation was found between the concentrations of MBP and IL-16 in serum. Conclusion MBP can be detected during the onset of MS. IL-16 is mainly induced within CNS and participates in the inflammation of MS.