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藻酸双酯钠、复方丹参、川芎嗪对血粘度及血脂作用的比较
引用本文:曹道元,曹仕琼. 藻酸双酯钠、复方丹参、川芎嗪对血粘度及血脂作用的比较[J]. 中国新药与临床杂志, 1991, 0(6)
作者姓名:曹道元  曹仕琼
作者单位:湖北省梨园医院,湖北省梨园医院 武汉 430077,武汉 430077
摘    要:缺血性心、脑血管疾病伴血粘度增高226例(男195例,女31例;年龄65±SD7yr)其中藻酸双酯钠(PSS)组83例(伴血脂增高68例),用PSS100mg加5%-10%葡萄糖液300mL,静滴,qd×10d;丹参组78例(45例),用复方丹参16mL;川芎嗪组65例(40例),用盐酸川芎嗪8mL;分别加5%-10%葡萄糖液300mL,静滴,qd×14d;3组降血液粘度(血脂)有效率依次为76%(93%),46%(42%)及43%(35%);PSS组明显优于后2组(P<0.01)。

关 键 词:粘多糖类/治疗应用  血液粘度  血脂过多  丹参  川芎嗪

Comparison among polysaccharide sulfate, Danshen Compound and ligustrazine on blood viscosity and blood lipids
CAO Dao-Yuan,CAO Shi-Qiong. Comparison among polysaccharide sulfate, Danshen Compound and ligustrazine on blood viscosity and blood lipids[J]. Chinese Journal of New Drugs and Clinical Remedies, 1991, 0(6)
Authors:CAO Dao-Yuan  CAO Shi-Qiong
Abstract:Patients (M 195, F 31; age 65 ± SD 7 yr) with ischemic cardiovascular and cerebrovascular diseases having hyperviscosity of blood were divided into 3 groups: 83 patients (hyperlipidemia in 68) were treated with polysaccharide sulfate (PSS) iv drip 100 mg/d x 10 d as a course, 78 patients(hyperlipidemia in 45) were treated with Danshen Compound iv drip 16 mL/d, and 65 patients (hyperlipidemia in 40) took ligustrazine iv drip 8 mL/d x 14 d as a course. The response rate of the reduction of blood viscosity (blood lipids) in the PSS group was 76% (93%). Whereas in the Danshen Compound group was 46 % (42 %) and the ligustrazine group was 43 % (35 %). Hence the clinical efficacy of the PSS group is superior to the Danshen Compound group and the ligustrazine group(P<0.01).
Keywords:mucopolysaccharides/therapeutic use  blood viscosity  hyperlipidemia/ drug therapy  Salvia miltiorrhiza  ligustrazine  
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