微量元素与血脂和血糖的相关性

目的研究上海地区成年人全血微量元素与血脂和血糖的关系。方法选择上海地区2个社区18岁以上成年调查对象245名，测定其体内铁（Fe）、锌（zn）、铜（Cu）、镁（Mg）、铅（Pb）、锰（Mn）、镉（cd）等各种元素含量及体重指数（BMI）、腰臀比（WHR）和血压水平，分析上述指标与血脂和血糖之间的关系。结果与正常对照组相比，高脂血症组全血Fe、Mn水平显著降低，Zn、Zn／cu水平显著升高（P〈0．05或P〈0．01）；高血糖组全血Zn、Zn／Cu和Mn水平显著降低，cu和Pb水平显著升高（P〈0．05或P〈0．01）；在高脂血症和高血糖组均存在低Mg高Cd趋势，但差异无统计学意义（P〉0．05）。结论高脂血症和高血糖患者体内大多数微量元素都存在代谢异常，及时纠正微量元素代谢紊乱对高脂血症和高血糖的防治和转归可能具有一定价值。

A survey on the relationship between trace elements and blood lipids and glucose in Shanghai adults

Objective To study the relationship between trace elements and blood lipids and glucose in Shanghai adults. Methods Totally 245 subjects aged above 18 years from two communities in Shanghai were en-rolled into this study. Blood trace elements (Fe, Zn, Cu, Mg, Pb, Mn, and Cd) were examined with atom ab-serption spectrophotometry. Body mass index (BMI), waist hip rate (WHR), and blood pressure (SBP, DBP)were also determined. Results Compared with the normal control group, plasma Fe and Mn levels were signifi-cantly lower while Zn and Zn/Cu levels were significantly higher in hyperlipemia group (P <0.05 or P <0. 01 ) ;plasma Zn, Zn/Cu, and Mn levels were significantly lower while Cu and Pb levels were significantly higher in dia-betes mellitus group (P <0. 05 or P <0. 01 ) . A tendency of lower Mg and higher Cd levels were also found in both disease groups, but there were no statistical significance ( P >0. 05 ). Conclusions The metabolism of trace elements is abnormal in patients with hyperlipemia and diabetes mellitus. Intervention of these trace elements disor-der may be valuable in the prevention and treatment of these diseases.