苯那普利致咳嗽不良反应的监测及其危险因素研究

目的 研究苯那普利相关咳嗽不良反应的危险因素。方法 对1831例高血压患者进行连续3年的用药观察，随访记录咳嗽不良反应发生情况，并嵌套病例对照研究，进行危险因素分析。结果 服用苯那普利后半年内，咳嗽不良反应的发生率女性为18．35％，男性为12．11％。logistic回归分析显示，女性(OR＝2．193，95％CI：1．500—3．206)、肾功能失代偿的女性(OR＝3．432，95％CI：1．954—6．028)、女性65岁以上(OR＝1．672，95％CI：1．040—2．688)、男性饮白酒100g／日以上(OR＝2．478，95％CI：1．148—5．347)发生咳嗽不良反应的危险性增加。结论 女性、老年、饮白酒、肾功能失代偿是苯那普利致咳嗽不良反应发生的可能危险因素，但不是主要的危险因素。

Postmarketing surveillance of benazepri-l related cough and related risk factors analysis on hypertensives

Objective To investigate the risk factors of benazepril related cough. Methods Case-control study nested in a community-based postmarketing surveillance was carried out. One thousand eight hundred and thirty-one hypertensive patients screened from a Chinese community were recruited to take benazepril for 3 years. Demographic characteristics and behavior risks were investigated and the level of uric acid and creatinine were tested at baseline. Episodes of benazepril related cough during follow period were recorded. Results Within half a year of administration, the incidence rates of cough were as high as 18.35 % in women and 12.11 % in men. Incidence decreased significantly when time went by. Two years later of administration, first occurrences of cough were still seen. Based on logistic regression analysis, women were more likely to develop cough ( OR = 2.193 ,95% CI : 1.500- 3.206 ). The association between decompensated kidney function and cough occurrence was only detected in women ( OR = 3.432 ,95% CI : 1.954- 6.028 ). Women aged 65 or more had 1.672 (95% CI : 1.040- 2.688 ) times risk than women aged 35 to 64 years. In men, the OR of developing cough was 1.689 (95% CI : 0.976- 2.924 ) for daily drinking alcohol less than 100 g but increased to 2.478 (95% CI : 1.148- 5.347 ) when drinking 100 g or more, but not the determinant ones.Conclusion Women, older age, drinking alcohol and decompensated kidney function were the possible risk factors for benazepril related cough,but not the determinant ones.