神经生长因子治疗颈脊髓过伸性损伤20例疗效分析

目的评价神经生长因子(NGF)对颈脊髓过伸性损伤的疗效。方法40例颈脊髓过伸性损伤患者随机分为治疗组和对照组,分别以NGF及胞二磷胆碱治疗,观察两组疗效。结果肌力恢复:治疗组总有效率为93.8%,对照组为66.7%,两组比较差异有显著意义(P<0.05)。感觉恢复:治疗组总有效率95%,对照组为65%,两组比较差异有显著意义(P<0.05)。结论NGF对脊颈髓过伸性损伤疗效肯定,优于胞二磷胆碱。进一步证实外源性NGF可以提高神经损伤处内源性NGF含量和活性。

The analysis of the efficacy of nerve growth factor(NGF) on the hyperextension injuries of the cervical spinal segment in 20 cases

Objective To evaluate the curative effect of nerve growth factor(NGF) on the hyperextension injuries of the cervical spinal segment.Methods 40 cases with the hyperextension injuries of the cervical spinal segment were randomly divided into treatment group in which NGF was administrated and control group in which cytidine diphosphate choline was administrated,and subsequently observed their own curative effect.Results The total effective rate of myodynamic recovery was 93.8% in treatment group and 66.7% in control group.The total effective rate of muscular sensational recovery was 95% in treatment group and 65% in control group.There was a significant difference in both myodynamic recovery and muscular sensational recovery between two groups(P<0.05).Conclusions The curative effect of NGF on the hyperextension injuries of cervical spinal segment is better than what cytidine diphosphate choline does.It is further confirmed that the administration of exogenous NGF may improve the neurotrophic activities and contents of endogenous NGF where the nerves are injured.