| 孕期补充二十二碳六烯酸对母鼠脂肪代谢及CPT-Ⅰ mRNA表达的影响 |
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| 引用本文： | 龚清海,张晓宏,徐琛玮. 孕期补充二十二碳六烯酸对母鼠脂肪代谢及CPT-Ⅰ mRNA表达的影响[J]. 浙江预防医学, 2010, 22(4): 1-4 |
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| 作者姓名： | 龚清海 张晓宏 徐琛玮 |
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| 作者单位： | 宁波大学医学院预防医学研究所,浙江,宁波,315211 |
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| 摘 要： | 目的探讨孕期补充二十二碳六烯酸(DHA)对母鼠脂肪代谢和肉碱棕榈酰转移酶-Ⅰ(CPT-Ⅰ)mRNA表达的影响。方法将SD雌鼠按体重随机分成A、B、C3组,孕期分别食用补充高剂量DHA膳食(A)、补充低剂量DHA膳食(B)、普通膳食(C),待母鼠分娩,实验结束。观察母鼠妊娠期间体重变化及各组子鼠出生数量、出生体重情况,检测母鼠产后肾周脂肪含量、血清甘油三酯(TG)、血清总胆固醇(TC)、血清高密度脂蛋白(HDL-C)水平、瘦素(Leptin)及肝脏组织中CPT-ⅠmRNA的表达丰度。结果各组孕鼠妊娠时间、产子数量、子鼠出生体重均无明显差异,但A、B组的母鼠产后血清甘油三酯水平低于C组;A组母鼠孕期增重量、肾周脂肪含量、总胆固醇、瘦素水平均明显低于C组;A、B组母鼠产后肝脏组织的CPT-ⅠmRNA水平高于C组。结论孕期补充DHA有调节母体血脂、减少体内脂肪含量的作用,而CPT-Ⅰ基因表达的上调可能是其一潜在机制。
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| 关 键 词： | 孕期 DHA 肉碱棕榈酰转移酶-Ⅰ（CPT—Ⅰ） |
The Effect of Docosahexenoic Acid Supplementation on Lipid Metabolism and CPT-I mRNA Expression during Pregnancy |
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| GONG Qing-hai,ZHANG Xiaohong,XU Chenwei. The Effect of Docosahexenoic Acid Supplementation on Lipid Metabolism and CPT-I mRNA Expression during Pregnancy[J]. Zhejiang Journal of Preventive Medicine, 2010, 22(4): 1-4 |
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| Authors: | GONG Qing-hai ZHANG Xiaohong XU Chenwei |
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| Affiliation: | GONG Qing-hai,ZHANG Xiao-hong,XU Chen-wei,et al.Department of Preventive Medicine,Ningbo University School of Medicine,Ningbo 315211,China |
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| Abstract: | Objective To explore the influence of docosahexenoic acid (DHA) spplementation during pregnancy on fat metabolism and CPT-I mRNA expression in maternal rats.Methods Female SD rats were randomly divided into A,B,C three groups,which were fed with high-dose DHA dietary supplement,low-dose DHA dietary supplement and normal diet,respectively.The following indexes were detected in pregnancy rats of every group:weight change,pregnancy time,perirenal fat content,serum total cholesterol (TC),triglyceride level (TG)... |
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| Keywords: | DHA |
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