纳米氧化锌抗菌性能及机制*◆

 背景：氧化锌作为一种活性氧化物类抗菌材料,拥有良好的生物相容性、安全性以及长效性。目的：总结纳米氧化锌的抗菌性能及其抗菌机制。方法：应用计算机检索1995-12/2011-02 Elsevier (ScienceDirect)及Web of Science期刊引文索引数据库相关文章,检索词为“antibacterial properties of nano-zinc oxide”,并限定文章语言种类为English。同时计算机检索1995-12/2011-02 CNKI学术总库及万方数据库相关文章,检索词为“纳米氧化锌抗菌性能”,并限定文章语言种类为中文。共检索到文献75篇。结果与结论：纳米氧化锌在很多方面的杀菌性能都很强,并且由于其良好的生物相容性、安全性以及长效性,可以取代医学上其他活性氧化物抗菌材料。文章从纳米氧化锌抗菌性能改性,以及形貌与结构对抗菌性的影响等方面,详细总结了纳米氧化锌的抗菌性能及其抗菌机制,但是如何提高纳米氧化锌的利用率和杀菌性能,如何使纳米氧化锌应用于更多细菌的抑制或更广阔的领域,都需要人们的继续努力。关键词：纳米氧化锌;抗菌材料;抗菌机制;生物材料;综述文献 doi:10.3969/j.issn.1673-8225.2012.03.033 

Antibacterial properties and mechanism of nano-zinc oxide

BACKGROUND: The zinc oxide has a good biocompatibility, security and long effectiveness, and can be used as a type of antibacterial material of active oxide category. OBJECTIVE: To summarize the antibacterial properties and mechanism of nano-zinc oxide (nano-ZnO). METHODS: A computer-based online search of related papers from December 1995 to February 2011 was performed in Elsevier (Science Direct) and Web of Science databases using the key words of “antibacterial properties of nano-ZnO” in English, and in CNKI and Wanfang databases using the key words of “antibacterial properties of nano-ZnO” in Chinese. Totally 75 literatures were selected. RESULTS AND CONCLUSION: The nano-ZnO has a strong bactericidal property in many fields. It can replace other materials of active oxide category based on its good biocompatibility, security and long effectiveness. The antibacterial properties and mechanism of nano-ZnO were summarized in this study from the sides of modified antibacterial properties and the effects of morphology and structure of nano-ZnO on antibacterial properties. However, more studies are in need to solve how to improve the utilization and antibacterial properties, and to expand the applications of nano-ZnO in antibacterial and other fields.