器官移植前保存的理论研究与临床应用

背景：器官移植前的活性是器官移植后功能恢复的关键,也是器官保存医学的难题之一。目的：综述了器官的保存方法、保存液以及各个器官国内外的保存现状,以便寻找不同器官的最佳保存方法和保存液,为器官保存提供理论依据。方法：应用计算机检索万方、维普数据库和PubMed数据库中1998-01/2011-09关于器官移植前保存的文章,在标题和摘要中以“器官;移植;保存”或“organ;transplant;preservation”为检索词进行检索。选择文章内容与器官移植前保存相关,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到186篇文献,根据纳入标准选择20篇文章进行综述。结果与结论：对器官保存方法的了解,有利于根据研究现状选择合适的保存方法。器官保存液是器官活性保持的关键,现存保存液较多,不同保存液对不同的器官保存效果具有一定的差异,通过选择合适的保存液使需要移植的器官保存效果达到最佳,从而使移植后的器官功能恢复的最好。通过对器官移植前保存方法和保存液的研究,了解不同器官的合适的保存方法和保存液将有利于器官保存医学的进一步发展。

Clinical application and theoretical study of organ preservation before transplantation

BACKGROUND: Organ activity before organ transplantation is the key of functional recovery and is also a difficult medical problem of organ preservation.OBJECTIVE: To review the organ preservation methods, preservation solution and current preservation situation at home and abroad in order to find the best preservation methods and preservation solution for providing the theory basis of organ preservation. METHODS: Wanfang, VIP and PubMed databases were retrieved for articles related to the organ preservation before transplantation published from January 1998 to September 2011. Key words were “organ; transplantation; preservation” in Chinese and English. Articles which published recently or in the authoritative magazines were preferred in the same field. A total of 186 articles were obtained, and 20 articles were involved for summarization according to inclusion criteria.RESULTS AND CONCLUSION: To understand the methods of organ preservation is beneficial for selecting appropriate preservation methods according to the current research situation. Organ preservation solution is the key to keep organ activity. Extant preservation solution is sufficient, so the effect of different preservation solutions on different organ preservations is different. To select the proper preservation solution is to achieve the best effect of transplanted organ preservation and to restore the best organ function after transplantation. To study the methods of organ preservation before transplantation, preservation solution and understand the different organs with the appropriate preservation method and preservation solution is beneficial for the further medical development of organ preservation.