肾素-血管紧张素-醛固酮系统与矿工高血压关系初步研究

目的：探讨肾素-血管紧张素-醛固酮系统与矿工高血压之间的关系。方法：对地面与井下作业的煤矿工人进行问卷调查和血压、身高、体重的测量，用放射免疫测定法测定高血压与非高血压矿工血浆肾素活性（PRA）、血管紧张素Ⅱ（Ang Ⅱ）和醛固酮（ALD）水平。结果：高血压组矿工血浆PRA、Ang Ⅱ和ALD水平显著高于非高血压组矿工（均P<0.01），矿工平均动脉血压与血浆PRA、Ang Ⅱ和ALD水平呈显著正相关（r=0.371、r=0.12和r=0.352）。在高血压矿工中，井下作业组血浆PRA、AngⅡ和ALD水平显著高于地面作业组（均P<0.01），且井下作业组中又以安装维修组最高；高盐饮食组血浆PRA、Ang Ⅱ和ALD水平显著高于正常饮食组（均P<0.01），而年龄、工龄、家族史、体重指数、吸烟和酗酒等因素对高血压矿工血浆PRA、AngⅡ和ALD水平均无显著影响。结论：肾素-血管紧张素-醛固酮系统可能介导了煤矿井下作业与盐致矿工高血压的发病过程。

Preinninary study on relationship between renin- angiotensin

AIM: To study the relationship between renin-angiotensin-aldosterone system and hypertension in coal miners. METHODS: The coal miners received questionnaire investigation and their blood pressure, height and weight were measured, plasma renin activity (PRA), plasma angiotensin Ⅱ(Ang Ⅱ) and aldosterone (ALD) were tested by means of radio immunoassay in coal miners with hypertension and nor-hypertension. RESULTS: It was found that levels of PRA, Ang Ⅱ and ALD were significantly higher in hypertensive group than in nor-hypertensive group (all P<0.01), average blood pressure had positive correlation with levels of PRA, Ang Ⅱ and ALD in all miners (r=0.371, r=0.412 and r=0.352). In coal miners with hypertension, levels of PRA, Ang Ⅱand ALD were significantly higher in underpit operation group than in ground operation group (all P<0.01), and install-repair group's were highest in underpit operation group; Levels of PRA, Ang Ⅱand ALD were significantly higher in high-salt diet group than in normal diet group (all P<0.01), but there was no significant change in age, length of service, family history, body mass index, smoking and alcoholism on levels of PRA, Ang Ⅱ and ALD. CONCLUSION: The renin-angiotensin-aldosterone system may potentially mediate underpit operation-and salt-induced hypertension pathogenesis in coal miners.