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| JNKK1蛋白表达对乳腺癌转移和预后的影响 | |
| 引用本文： | 周健,袁传涛,戴功. JNKK1蛋白表达对乳腺癌转移和预后的影响[J]. 中国医药导报, 2010, 7(16): 11-13 |
| 作者姓名： | 周健 袁传涛 戴功 |
| 作者单位： | 1. 潍坊医学院药理学教研室,山东,潍坊,261053 2. 济宁医学院附属医院病州科,山东,济宁,272000 |
| 基金项目： | 山东省教育厅科技计划项目 |
| 摘 要： | 目的：探讨JNKK1基因表达对乳腺癌转移和预后的影响。方法：应用免疫组织化学方法检测103例乳腺癌组织中JNKK1蛋白表达,结合乳腺癌临床表现进行分析。结果：在乳腺癌组织中,JNKK1蛋白阳性表达率为44.7%（46/103）,阴性表达率为55.3%（57/103）。JNKK1蛋白阴性表达的乳腺癌转移率高（P〈0.01）,分化程度差,患者大于5年生存率低（P〈0.01）。结论：JNKK1蛋白表达与乳腺癌转移密切相关,检测JNKK1蛋白表达可作为诊断与治疗乳腺癌的参考指标。 |
| 关 键 词： | 乳腺癌 抑癌基因 JNKK1 转移 免疫组织化学 |
The research of JNKK1 expression and the effect on the metastasis and prognosis of breast carcinoma |
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| ZHOU Jian,YUAN Chuantao,DAI Gong. The research of JNKK1 expression and the effect on the metastasis and prognosis of breast carcinoma[J]. China Medical Herald, 2010, 7(16): 11-13 | |
| Authors: | ZHOU Jian YUAN Chuantao DAI Gong |
| Affiliation: | 1.Department of Pharmacology,Weifang Medical College,Weifang 261053,China;2.Department of Pathology,the Affiliated Hospital of Jining Medical College,Jining 272000,China) |
| Abstract: | Objective：To investigate the effect of JNKK1 expression with potential metastasis and prognosis of breast carcinoma. Methods：Immunohistochemistry was used to detect and analyze JNKK1 expression in 103 cases of breast carcinoma. Results：The positive expression rate of JNKK1 was 44.7%（46/103） ,and the negative rate was 55.3%（57/103） . Breast carcinoma patients with positive expression of JNKK1 had higher metastatic rate（P〈0.01） and poorer survival rate in 5 years（P〈 0.01） . Conclusion：The expression of JNKK1 is closely related to the potential of metastasis in breast carcinoma. JNKK1 may be a prognostic and treatment indicator in breast carcinoma. |
| Keywords: | JNKK1 |
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