小边界适形调强放疗与指南边界适形调强放疗联合替莫唑胺化疗在脑恶性胶质瘤的应用及其相关因素的回顾性研究

正脑恶性胶质瘤作为难治性的肿瘤之一,在我国的年患病率约为(6~9)/10万,其3年死亡率在全身肿瘤中位于第3位,仅次于胰腺癌与肺癌~1-2]。在采取最大限度的安全切除术的基础上进行放射治疗与给予替莫唑胺同步化疗是治疗脑恶性胶质瘤的首选手段~3-4]。目前,有关放疗操作以适形调强放疗为主,且有关脑恶性胶质瘤的放疗剂量及其时间已形成一致看法,而有关放疗靶区的看法仍未统一~5]。因此,本研

Retrospective study of small border limited margins intensity-modulated radiotherapy and guidelines limited margins combined with temozolomide chemotherapy for the treatment of patients with malignant glioma and study on the related factors

Objective To retrospectively study the application of small border and guidelines limited margins intensity-modulated radiotherapy combined with temozolomide chemotherapy for the treatment of patients with malignant glioma and its related factors. Methods 104 cases of malignant glioma were selected in our hospital, and were randomly divided into the observation group underwent small boundary limited margins intensity-modulated radiotherapy and the control group received guidelines limited margins intensity-modulated radiotherapy, with 52 cases in each group.104 cases were all treated with radiotherapy combined with temozolomide chemotherapy and the curative effects and survival situation of one year were compared between the two groups and the related factors were analyzed. Results The total efficiency of the two groups showed no significant difference (P>0.05); the progression free survival of 1 year, PFSR-1 and survival rate of 1 year showed no significant difference between the two groups (Pall>0.05); the surgery situation and MGMT methylation were influencing factors on the curative effects (P both<0.05), and the surgery situation was the influencing factors on progression free survival of 1 year (P<0.05). Conclusion Small border and guidelines limited margins intensity-modulated radiotherapy combined with temozolomide chemotherapy have similar effects in the treatment of patients with malignant glioma, and the surgery situation is an important influencing factor on the prognosis.