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Possible Anandamide and Palmitoylethanolamide involvement in human stroke |
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| Authors: | Marcello Naccarato Daniela Pizzuti Stefania Petrosino Marco Simonetto Laura Ferigo Fabio Chiodo Grandi Gilberto Pizzolato Vincenzo Di Marzo |
| Affiliation: | (1) Department of Medical, Technological and Translational Sciences, Neurology Unit, University of Trieste, Strada di Fiume 447, 34100 Trieste, (TS), Italy;(2) Department of Surgical and Gastroenterological Sciences, University of Padova, Via Giustiniani 5, Padova, (PD), Italy;(3) Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Pozzuoli, (NA), Italy |
| Abstract: | BackgroundEndocannabinoids (eCBs) are ubiquitous lipid mediators that act on specific (CB1, CB2) and non-specific (TRPV1, PPAR) receptors. Despite many experimental animal studies proved eCB involvement in the pathogenesis of stroke, such evidence is still lacking in human patients. Our aim was to determine eCB peripheral levels in acute stroke patients and evaluate their relationship with clinical disability and stroke volume. |
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