Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study |
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| Authors: | Ornit Chiba-Falek Marshall Nichols Sunil Suchindran John Guyton Geoffrey S Ginsburg Elizabeth Barrett-Connor Jeanette J McCarthy |
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| Affiliation: | (1) Institute for Genome Sciences and Policy, Duke University Medical Center, 27710 Durham, NC, USA;(2) Division of Endocrinology, Duke University Medical Center, 27710 Durham, NC, USA;(3) Department of Family and Preventive Medicine, University of California at San Diego, 92121 San Diego, CA, USA |
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| Abstract: | Background Several studies have noted that genetic variants of SCARB1, a lipoprotein receptor involved in reverse cholesterol transport, are associated with serum lipid levels in a sex-dependent
fashion. However, the mechanism underlying this gene by sex interaction has not been explored. |
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