| 高血压、冠心病患者血浆组织因子及组织因子途径抑制物活性变化 |
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| 引用本文： | 肖振军,王伟,汉建忠,何晓凡,李俊成.高血压、冠心病患者血浆组织因子及组织因子途径抑制物活性变化[J].中南大学学报(医学版),1999,24(3):251-252. |
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| 作者姓名： | 肖振军 王伟 汉建忠 何晓凡 李俊成 |
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| 作者单位： | 1. 湖南医科大学,附属湘雅医院老年病科,长沙,410008
2. 湖南医科大学,生理教研室,长沙,410078 |
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| 基金项目： | 湖南省科委课题,国家自然科学基金 |
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| 摘 要： | 目的：观测高血压及冠心病患者血浆ＴＦ活性与ＴＦＰＩ活性的变化。方法：采用二步法测定血浆ＴＦ活性；以Ｓａｎｄｓｅｔ发色底物法测定ＴＦＰＩ活性。结果：高血压与冠心病患者血浆ＴＦ与ＴＦＰＩ活性均高于正常对照组（Ｐ＜０．０５）。结论：凝血功能亢进可能参与了高血压、冠心病形成，提示血浆ＴＦ和ＴＦＰＩ活性测定值可作为高血压、冠心病辅助性诊断指标。
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| 关 键 词： | 高血压 冠状动脉硬化 组织因子 组织因子途径抑制物 |
Changes of TF and TFPI activities in patients with hypertension or coronary atherosclerotic heart disease |
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| Xiao Zhenjun,Wang Wei,Han Jianzhong,He Xiaofan,Li Juncheng.Changes of TF and TFPI activities in patients with hypertension or coronary atherosclerotic heart disease[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1999,24(3):251-252. |
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| Authors: | Xiao Zhenjun Wang Wei Han Jianzhong He Xiaofan Li Juncheng |
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| Abstract: | Object: to investigate the changes of tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in patients with hypertension or coronary atherosclerotic heart(CAH) disease. Methods: TF activity was measured by two stage assay, and TFPI activity was detected according to Sandset's method. Results: Plasma TF activity in both patients with hypertension and patients with CAH disease was higher than that of normal control( P <0.05). Conclusion: Hypercoagulative state may be involed in the pathogenetic processes of hypertension and CAH diseases. TF and TFPI activities have the likelihood to become the accessory diagnostic indexes for hypertension and CAH diseases. |
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| Keywords: | hypertension coronary arteriosclerosis tissue factor tissue factor pathway inhibitor |
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