A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future |
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| Affiliation: | 7. University of Ghana, Accra, Ghana;8. Imperial College London, London, United Kingdom;9. European Medicines Agency, Amsterdam, the Netherlands;10. National Institute for Communicable Diseases and University of the Witwatersrand, Johannesburg, South Africa;11. University of Hong Kong, Hong Kong;12. University of Bergen, Bergen, Norway;13. University of Melbourne, Melbourne, Australia;14. PATH Center for Vaccine Innovation & Access, Washington, D.C., USA;15. Christian Medical College, Vellore, India;p. US Centers for Disease Control & Prevention (Retired), Atlanta, GA, USA;q. Icahn School of Medicine at Mount Sinai, New York City, NY, USA;r. Mahidol University, Bangkok, Thailand;s. National Institutes of Health, Bethesda, MD, USA;t. Institute of Experimental Medicine, St. Petersburg, Russia;u. Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil;v. Food and Drug Administration, Silver Spring, MD, USA;1. Center for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, MN, USA;2. Center for Infectious Disease Research and Policy, C315 Mayo Memorial Building, MMC 263, 420 Delaware Street, SE, Minneapolis, MN 55455, USA;3. The Global Funders Consortium for Universal Influenza Vaccine Development, The Task Force for Global Health, and the US Centers for Disease Control and Prevention, Atlanta, GA, USA;4. World Health Organization, Geneva, Switzerland;5. The Sabin Vaccine Institute, Washington, D.C., USA;6. Wellcome Trust, London, United Kingdom |
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| Abstract: | ![]()
Improved influenza vaccines are urgently needed to reduce the burden of seasonal influenza and to ensure a rapid and effective public-health response to future influenza pandemics. The Influenza Vaccines Research and Development (R&D) Roadmap (IVR) was created, through an extensive international stakeholder engagement process, to promote influenza vaccine R&D. The roadmap covers a 10-year timeframe and is organized into six sections: virology; immunology; vaccinology for seasonal influenza vaccines; vaccinology for universal influenza vaccines; animal and human influenza virus infection models; and policy, finance, and regulation. Each section identifies barriers, gaps, strategic goals, milestones, and additional R&D priorities germane to that area. The roadmap includes 113 specific R&D milestones, 37 of which have been designated high priority by the IVR expert taskforce. This report summarizes the major issues and priority areas of research outlined in the IVR. By identifying the key issues and steps to address them, the roadmap not only encourages research aimed at new solutions, but also provides guidance on the use of innovative tools to drive breakthroughs in influenza vaccine R&D. |
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