Role of OmpA in the Multidrug Resistance Phenotype of Acinetobacter baumannii |
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| Authors: | Younes Smani Anna Fàbrega Ignasi Roca Viviana Sánchez-Encinales Jordi Vila Jerónimo Pachón |
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| Affiliation: | aInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville, Spain;bDepartment of Clinical Microbiology, School of Medicine, Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain |
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| Abstract: | Acinetobacter baumannii has emerged as a nosocomial pathogen with an increased prevalence of multidrug-resistant strains. The role of the outer membrane protein A (OmpA) in antimicrobial resistance remains poorly understood. In this report, disruption of the ompA gene led to decreased MICs of chloramphenicol, aztreonam, and nalidixic acid. We have characterized, for the first time, the contribution of OmpA in the antimicrobial resistance phenotype of A. baumannii. |
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