Assisted therapy with platelet-rich plasma for burn patients: A meta-analysis and systematic review |
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| Affiliation: | 1. School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;2. Division of Plastic Surgery, Department of Surgery, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;3. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan;4. Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;5. Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan;1. Emergency Medical Services Department, Singapore Civil Defence Force, Singapore 408827, Singapore;2. Fire Research Unit, Fire Safety and Shelter Department, Singapore Civil Defence Force, Singapore 408827, Singapore;1. Chelsea and Westminster Hospital NHS Foundation Trust, London, UK;2. Cancer and Surgery, Imperial College London, UK |
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| Abstract: | IntroductionPlatelet-rich plasma (PRP) therapy has been used in different medical fields, but its effectiveness in burn wound healing remains debatable. In this study, we performed a systematic review and meta-analysis of the available evidence on burn patients treated with PRP to evaluate the safety and efficacy of the treatment.MethodsRandomized controlled trials evaluating the efficacy of PRP in patients with burn injuries were selected. Eligible retrospective studies were abstracted and assessed for the risk of bias by two reviewers and results of mean time to complete epithelization and wound closure rate in the included studies were analyzed. Studies on the correlation between PRP and burn wound healing published in English or Chinese before March 2020 were retrieved from PubMed.ResultsEight studies (including 449 patients) met our inclusion criteria. Qualitative analysis revealed that compared with the control group, the PRP group had significantly better wound closure rates at weeks 2 (mean difference (MD): 12.79 [95% confidence interval (CI): 7.08, 18.49]; I2: 0%; p < 0.0001) and 3 (MD: 12.66 [95% CI: 5.97, 19.34]; I2: 55%; p = 0.0002) and time to complete epithelialization (MD: −3.45 [95% CI: −4.87, −2.04] (days); I2: 0%; p < 0.00001). There was no significant difference in infection rate or graft take rate.ConclusionsPRP application can accelerate wound closure, however, it has no effect on the rates of wound infection and graft take rate. |
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| Keywords: | Platetlet-rich plasma PRP Burn Burn wounds Healing Epithelialization Graft take |
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