Effects of combined Pulsed Dye Laser and Fractional CO2 Laser treatment of burn scars and correlation with plasma levels of collagen type I,MMP-2 and TIMP-1 |
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| Affiliation: | 1. Pediatric Surgery Department, Medical University of Bialystok, Poland;2. Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Poland;3. Biophysics Department, Medical University of Bialystok, Poland;1. Plastic Surgery and Burns Research Unit, The University of Bradford, Richmond Road, Bradford, BD7 1DP, UK;2. Department of Life Sciences, The University of Bradford, Richmond Road, Bradford, BD7 1DP, UK;3. Pinderfields Hospital, Aberford Road, Wakefield, WF1 4DG, UK;4. Bradford Teaching Hospitals, Duckworth Lane, Bradford, BD9 6RJ, UK;1. School of Nursing, National Defense Medical Center, 4F., No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, Taiwan;2. Department of Nursing, Tri-Service General Hospital, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, Taiwan;3. Department of Nursing, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan;4. School of Public Health, National Defense Medical Center, No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, Taiwan;5. Taiwanese Injury Prevention and Safety Promotion Association, Room 4112, No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, Taiwan;6. Department of Medical Research, Tri-Service General Hospital, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, Taiwan;7. Graduate Institute of Life Sciences, National Defense Medical Center, No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, Taiwan;1. Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia, Cyprus;2. Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia, Cyprus;3. Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Cyprus Health and Social Sciences University, Morphou, Cyprus;4. Vocational School of Health-Related Professions, Marmara University, Istanbul, Turkey;1. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands;2. Burn Centre, Maasstad Hospital, Rotterdam, The Netherlands;1. Burn Centre, Maasstad Hospital, Rotterdam, The Netherlands;2. Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands;1. Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA;2. Department of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi;3. Department of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, USA;1. Department of Intensive Care Medicine, University Hospital of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8556, Japan;2. Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan;3. Occupational Health Data Science Center, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan;4. Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;5. Department of Emergency and ICU, Steel Memorial Yawata Hospital, 1-1-1 Harunomachi, Yahatahigashi-ku, Kitakyushu, Fukuoka 805-8508, Japan |
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| Abstract: | ![]()
Hypertrophic burn scars remain a significant burden for patients and a challenge for clinicians.The aimAssessement of the efficacy of combined Pulsed Dye Laser and Ablative Fractional CO2 Laser therapy on hyperthophic scars and correlation with plasma levels of MMP-2, TIMP-1 and alpha-1 type I collagen.Patients and methodsTwenty five pediatric subjects were enrolled into the study. Control group consisted of age-matched subjects admitted for surgical repair of inguinal hernia. For the assessment of the results of laser treatment we used the Vancouver scar scale (VSS), and Patient-Observer Scar Assessment Scale (POSAS). We also correlated clinical results with plasma levels of MMP-2, TIMP-1 and alpha-1 type I collagen.ResultsAll subjects reported the laser treatment resulted in improvement and were somewhat satisfied or very satisfied with their experience. No adverse events were reported. The levels of MMP-2, TIMP-1 and alpha-1 type I collagen in our patients with scars before laser threatment were higher in comparison to controls. We also found statistically significant decrease in the levels of MMP-2, TIMP-1 and alpha-1 type I collagen after laser treatment of burn scarsConclusionsOur study clearly shows that combined CO2-AFL treatment for burn scars improve texture, colour, function and alleviate pruritus. We believe that decrease in the levels of MMP-2, TIMP-1 and alpha-1 type I collagen after laser treatment of burn scars, reflects reduced dynamic of scar. |
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| Keywords: | Burn scars Laser treatment Pulsed Dye Laser Plasma Collagen type I MMP-2 TIMP-1 |
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