PROTEIN-LOSING ENTEROPATHY IN SYSTEMIC LUPUS ERYTHEMATOSUS |
| |
| Authors: | S. E. J. EDMUNDS V. GANJU B. R. BEVERIDGE M. A. FRENCH M. F. QUINLAN |
| |
| Affiliation: | Medical Registrar, Department of General Medicine, Sir Charles Gairdner Hospital, Nedlands, W.A.;Medical Registrar, Department of General Medicine, Sir Charles Gairdner Hospital, Nedlands, W.A.;Physician, Department of General Medicine, Sir Charles Gairdner Hospital, Nedlands, W.A.;Clinical Immunologist, Department of Clinical Immunology, Sir Charles Gairdner Hospital, Nedlands, W.A.;Physician, Department of General Medicine, Sir Charles Gairdner Hospital, Nedlands, W.A. |
| |
| Abstract: | Two patients with systemic lupus erythematosus (SLE) presented with anasarca, pleural effusions and severe hypoalbuminema, Both were demonstrated to have protein-losing enteropathy, a rare complication of SLE. Other causes of gastrointestinal protein loss were excluded. There were marked similarities in both cases including circulating ANF with speckled staining, anti-(U1)RNP antibodies and low serum complement levels. Complete remission was achieved in both with prednisolone. Anti-(U1)RNP may be a marker for a subset of SLE in which protein-losing enteropathy is a major manifestation. |
| |
| Keywords: | Systemic lupus erythematosus protein-losing enteropathy anti-(U1)RNP antibodies |
|
|
