Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010 |
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| Authors: | Colafigli M,Torti C,Trecarichi E M,Albini L,Rosi A,Micheli V,Manca N,Penco G,Bruzzone B,Punzi G,Corsi P,Parruti G,Bagnarelli P,Monno L,Gonnelli A,Cauda R,Di Giambenedetto S ARCA, UCSC Brescia HIV resistance study groups |
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| Affiliation: | Institute of Clinical Infectious Diseases, Catholic University of S. Heart, Rome, Italy. manuela76@inwind.it |
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| Abstract: | ![]()
Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-na?ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. |
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