Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice |
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| Authors: | J. K. Kruit P. H. C. Kremer L. Dai R. Tang P. Ruddle W. de Haan L. R. Brunham C. B. Verchere M. R. Hayden |
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| Affiliation: | (1) Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Ave, Vancouver, BC, Canada, V5Z 4H4;(2) Department of Surgery and Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; |
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| Abstract: | ![]()
Aims/hypothesis Cellular cholesterol accumulation is an emerging mechanism for beta cell dysfunction in type 2 diabetes. Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin secretion, indicating that impaired cholesterol efflux leads to beta cell dysfunction. In this study, we aimed to determine the role of the LDL receptor (LDLr) in islet cholesterol uptake and to assess the contributions of cholesterol uptake compared with efflux to islet cholesterol levels. |
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