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| 急性脑梗死患者血清S100B蛋白检测的临床意义 | |
| 引用本文： | 江秀龙,张旭. 急性脑梗死患者血清S100B蛋白检测的临床意义[J]. 福建医药杂志, 2009, 31(6): 95-96 |
| 作者姓名： | 江秀龙 张旭 |
| 作者单位： | 福建省立医院神经内科,350001 |
| 摘 要： | 目的探讨急性脑梗死患者血清S100B蛋白水平的变化及其对重症脑梗死的预测作用。方法选择发病24h内、符合入选条件的急性脑梗死患者65例（有18例发展成重症脑梗死），以同期体检者30例作为对照组。用ELISA法测定血清S100B蛋白浓度，同时对患者作神经功能缺损评分（NIHSS），所有患者依据发病后48～72h的脑CT或MRI扫描结果计算脑梗死体积。应用受试者工作曲线（ROC曲线）寻找预测重症脑梗死发生相应的S100g蛋白最佳临界值。结果重症脑梗死患者24h血清S100B蛋白值明显高于非重症患者（P〈0．05）。发病24hS100B蛋白测定值〉1．1μg／I，为最佳临界值，预测重症脑梗死的敏感度为94％，特异度为85％。结论检测急性脑梗死患者血清S100B蛋白可作勾预测重症脑梗死发生的参考指标。 |
| 关 键 词： | 急性脑梗死 重症脑梗死 S100B蛋白 |
Serum S100B protein predicts a malignant course of patients with acute cerebral infarction |
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| Jiang Xiulong,Zhang Xu. Serum S100B protein predicts a malignant course of patients with acute cerebral infarction[J]. Fujian Medical Journal, 2009, 31(6): 95-96 | |
| Authors: | Jiang Xiulong Zhang Xu |
| Affiliation: | Jiang Xiulong,Zhang Xu.Department of Neurology,Fujian Provincial Hospital,Fuzhou 350001,China |
| Abstract: | Objective To investigate whether measurements of serum astroglial protein S100B can predict a malignant course of acute cerebral infarction(ACI).Methods There were 65 patients(29 women)admitted within 24-hours after ACI.Eighteen patients developed malignant infarction.A total of 30 healthy subjects were selected as control group at the same time.Blood samples were drawn at 24-hours after symptom onset.Serum S100B protein concentrations were determined by ELISA.The sensitivity and specificity of S100B protei... |
| Keywords: | Acute cerebral infarction Malignant infarction S100B protein |
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