微量肝素对重度窒息并发SIRS新生儿的干预作用

目的探讨微小剂量肝素降低新生儿重度窒息并发全身炎症反应综合征(SIRS)的作用和机制,并观察其副作用。方法对我科2001年1月～2005年10月间94例重度窒息新生儿(不含新生早产儿窒息病例)作回顾性分析。治疗组48例,常规综合治疗基础上加用低分子肝素钠5U/(kg·次),皮下注射,每12h1次,连用3d。对照组46例,采用综合治疗。就组间1周内SIRS的发生率作对照分析。结果治疗组1周内SIRS发生率和对照组间存在比较显著差异(P<0.05〉,而新生儿颅内出血、上消化道出血、和皮下出血的发生情况比较无显著差异性(P均>0.05)。结论早期应用微小剂量肝素可有效降低重度窒息新生儿SIRS的发生率而不致增加继发器官出血的机会。

Clinal study of reducing the incidence of SIRS in newborns with severe asphyxia by early using trace heparin

Objective To investigate the effective and mechanism of reducing theincidence of systemic inflammaory response syndrome (SIRS) in newborns with severe asphyxia when trace heparin was early used, in the same time observed its side effects .Methods From Jan.2001 to Oct.2005 in our department ,94 cases of severe asphxia(not including premature infants with asphyxia)were retrospectively reviewd.In treatment group, 48 cases were received trace Sodium heparin,except for multipal treatment .The other 46 cases were known as control group(received multipal treatment). The incidence of SIRS was analyzed after having been treated for the first week.Results The incidence of SIRS in treatment group is less than the that of control group,s(p<0.05),there is no significant difference between the side effects such as neonatal intracranial heamorrhage(NIH),upper gastrointestinal bleeding(UGIB)and nderskin bleeding(USB)(p>0.05).Conclusion Early use of trace heparin could effectivly reduce the incidence of SIRS and not increase the opportunity of other organs bleeding taking place.