神经妥乐平对CHOP方案治疗非霍奇金淋巴瘤所致周围神经系统疾病的疗效观察

 目的 观察神经妥乐平对CHOP方案治疗非霍奇金淋巴瘤（NHL）所致周围神经系统疾病的疗效。方法 采用CHOP化疗方案出现周围神经系统疾病的65例NHL患者随机分为A、B、C三组。A组15例，未治疗；B组25例，弥可保针剂0.5 mg，肌肉注射，1次／d，2周；C组25例，神经妥乐平针剂7.2 Nu，静脉滴注，1次／d，2周。结果 治疗1周周围神经系统疾病好转率：B组20.0 %，C组56.0 %（P＜0.01）；治疗2周时其好转率分别为52.0 %和84.0 %（P＜0.01）；A组未见明显好转。结论 神经妥乐平对CHOP化疗方案治疗NHL所致周围神经系统疾病有治疗作用。

A clinical study of neurotropin in the treatment of peripheral neuritis caused by CHOP regimen in the NHL patient

Objective To observe the efficacy of neurotropin in treatment of the peripheral neuritis caused by CHOP regimen in the non-Hodgkin lymphoma（NHL）patient. Methods 65 patients with peripheral neuritis caused by CHOP regimen were divided into 3 groups. A group 15 patients as control group accepted chemotherapy only. B group: 25 patients were treated with mecobalam injection (0.5 mg, im, qd) for 2 weeks. C group: 25 patients were given with neurotropin injection (6 ml, im. qd) for 2 weeks. Results For 1 week treat－ment, the rate of improvement was 20.0 % and 56.0 % in mecobalam group and neurotropin group respectively（P ＜0.01）. For 2 weeks, the rate was 52.0 % and 84.0 %（P ＜0.01）. Conclusion The neurotropin has the ac－tion of treating the peripheral neuritis caused by CHOP regimen of chemotherapy in the NHL patient.