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| 冠心病双生子差异表达mRNAs筛选及功能分析 | |
| 引用本文： | 李彩红,苏洁,苏征. 冠心病双生子差异表达mRNAs筛选及功能分析[J]. 现代中西医结合杂志, 2019, 0(20): 2189-2192,2211 |
| 作者姓名： | 李彩红 苏洁 苏征 |
| 作者单位： | 中国人民解放军空军军医大学第一附属医院;中国人民解放军空军军医大学第二附属医院 |
| 摘 要： | 目的筛选冠心病-健康者双生子差异表达mRNAs,分析其在冠心病中的调控机制。方法选择3对冠心病-正常双生子为研究对象,其中3例冠心病患者为研究组,3例正常者为空白组。分别抽取2组受检者外周静脉血5 mL,Trizol法提取总RNA,Human Genome Array表达谱芯片筛选差异表达mRNAs,利用DAVID生物软件对差异表达mRNAs进行GO富集和KEGG通路分析。结果筛选出21个特异性差异表达mRNAs,其中3个上调,18个下调,这些基因主要参与了免疫调控。结论冠心病双生子存在差异表达的mRNAs,这些基因主要与免疫相关,参与了炎症因子的异常调控,可能是冠心病发生发展的关键病机之一。 |
| 关 键 词： | 冠心病 表达谱芯片 双生子 基因 |
Screening and functional analysis of differentially expressed mRNAs in twins with coronary heart disease |
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| LI Caihong,SU Jie,SU Zheng. Screening and functional analysis of differentially expressed mRNAs in twins with coronary heart disease[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2019, 0(20): 2189-2192,2211 | |
| Authors: | LI Caihong SU Jie SU Zheng |
| Affiliation: | (Xijing Hospital,the First Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,Shaanxi,China;the Second Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,Shaanxi,China) |
| Abstract: | LI Caihong;SU Jie;SU Zheng(Xijing Hospital,the First Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,Shaanxi,China;the Second Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,Shaanxi,China) |
| Keywords: | coronary heart disease expression profile chip twin gene |
| 本文献已被 CNKI 维普 等数据库收录！ | |