| 五灵脂B_1抑制大鼠胃酸分泌的实验研究 |
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| 引用本文： | 马冰,王雄文,邵跃斌,潘劲晖.五灵脂B_1抑制大鼠胃酸分泌的实验研究[J].山西中医学院学报,2002,3(4):18-19. |
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| 作者姓名： | 马冰 王雄文 邵跃斌 潘劲晖 |
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| 作者单位： | 广州市红十字会医院,广东,广州,510220 |
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| 基金项目： | 广州市中医药、中西医结合科研计划课题(穗卫中犤1998犦20号) |
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| 摘 要： | 目的:研究五灵脂萃取物B1保护胃黏膜的作用机理。方法:SD大鼠40只随机分为空白组、B1低剂量(45mg/kg)组,B1高剂量(90mg/kg)组及雷尼替丁(30mg/kg)组,结扎幽门,腹腔给药,2h后取出鼠胃计算胃液量及胃酸pH值,并检测血清胃泌素。结果:腹腔注射五灵脂B1高剂量组大鼠2h胃酸pH值为2.143±0.244,高于空白对照组1.650±0.321,但胃液量及血清胃泌素量无差别。
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| 关 键 词： | 五灵脂 胃酸 胃泌素 |
| 文章编号： | 1671-0258(2002)04-0018-02 |
| 修稿时间： | 2002年8月26日 |
The Inhibitory Effect of Faeces Trogoterorum Extract B1 on Gastric Secretion in Rats |
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| Ma Bing,Wang Xiongwen,Shao Yuebing et al..The Inhibitory Effect of Faeces Trogoterorum Extract B1 on Gastric Secretion in Rats[J].Journal of Shanxi College of Traditional Chinese Medicine,2002,3(4):18-19. |
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| Authors: | Ma Bing Wang Xiongwen Shao Yuebing |
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| Abstract: | Objective:To investigate the effect and mechan ism of Faeces Trogopterorum B 1 on gastric se-cretion in rats.Methods:Forty male SD rats were randomly divided into control group,ranitidine g roup(30mg /kg),B 1 group(45mg /kg),B 1 group(90mg /kg).The drug were administrated by intr aperitoneal injec-tion immediately after ligature of p ylorus and closing of abdomen,2hour s later,the rats were killed and stomach were removed.The volume and pH of gastric juice as well as serum gastrin were deter-mined.Results:The mean pH of gastric juice of B 1 group(90mg /kg)was 2.143±0.244.It was higher than that of the control group(1.650±0.321,P<0.05).But the volume of gastric juice and t he serum gastrin had no difference compared with that of the control group(P>0.05).Conclusion:Faeces Trogoterorum ex-tract B 1 can inhibite the secretion of gastric acid,but it has no effect on the serum gastr in of the rats. |
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| Keywords: | faeces trogoterorum gastrin gastric acidpH |
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