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| 普卢利沙星--新一代氟喹诺酮类抗菌药 | |
| 引用本文： | 贺娟,夏培元. 普卢利沙星--新一代氟喹诺酮类抗菌药[J]. 抗感染药学, 2006, 3(1): 5-9 |
| 作者姓名： | 贺娟 夏培元 |
| 作者单位： | 第三军医大学第一附属医院药学部、国家药品临床研究基地,重庆,400038;第三军医大学第一附属医院药学部、国家药品临床研究基地,重庆,400038 |
| 摘 要： | 普卢利沙星(NM441)是氟喹诺酮类抗菌药物NM394的前体药物。体内外实验和临床研究表明,NM441对G+菌和G-菌均具有强的广谱抗菌活性,安全性较好,适用于呼吸、泌尿等多种组织和器官系统细菌感染的治疗。并对其药物动力学、药理作用和临床应用等方面的研究进行了简要总结。 |
| 关 键 词： | 普卢利沙星 氟喹诺酮 药物动力学 |
| 文章编号： | 1672-7878（2006）01-0005-04 |
| 收稿时间： | 2005-08-15 |
| 修稿时间： | 2005-09-27 |
Prulifloxacin, A New Quinolone Antibacterial Drug |
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| HE Juan,XIA Pei-yuan. Prulifloxacin, A New Quinolone Antibacterial Drug[J]. Anti-infection Pharmacy, 2006, 3(1): 5-9 | |
| Authors: | HE Juan XIA Pei-yuan |
| Affiliation: | The First Hospital Affiliated with Third Military Medical University of PLA,Chongqing 400038,China |
| Abstract: | Prulifloxacin (NM441) is a prodrug of thiazeto-quinoline carboxylic acid derivative of NM394. In vitro and in vivo experiment and clinical research have proved that NM 441 has both safety and efficacy against both G and G- bacterium. NM441 is effective in the treatment of bacterial infections in respiratory apparatus,urinary system and other tissues or organs. This article briefly reviewed the current investigation progress of NM 441 in pharmacokinetics, pharmacologic action and clinical application. |
| Keywords: | Prulifloxacin Puinolone Pharmacokinetic |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |