小儿轮状病毒感染的肝脏损害

目的探讨轮状病毒肠炎引起肝脏损害的相关因素。方法对324例轮状病毒肠炎患儿常规检测肝功能、HBVM,甲、丙、丁、戊、庚肝IgM抗体和TORCH、CMV的血清抗体。结果 324例患儿的HBVM及甲、丙、丁、戊、庚肝IgM抗体、TORCH、CMV血清抗体均为阴性。41例出现ALT升高,肝脏损害发生率为12.65%,≤1岁者为15.97％,>1岁者为9.72%,两者差异有显著性(P<0.05);ALT升高与临床脱水程度相比较,二者无显著性差异(P>0.05);腹泻停止后复查ALT,均恢复正常。结论轮状病毒引起肠道外感染,肝脏是受累脏器之一。

Hepatic Damage by the Infection of Rovavirus on Children

Objective To investigate the correlative factors of the hepatic damage by the rovavitus enteritis.Methods We examined the liver function, HBVM, IgM, of HAV, HCV, HDV, HEV, HFV, TORCH, and serum antibody of CMV of 324 children with rovavirus enteritis.Results The results of liver function, HBVM, IgM of HAV, HCV, HDV, HEV, HFV, and TORCH, serum antibody of CMV were all negative but ALT in 41 cases increased.The efficacy rate of hepatic damage was 12.65% , 15.97% of patients less than 1 year old and 9.72% for those more than 1 year old, showed significant difference (P< 0.05) .But no significant difference showed between the increase of ALT and the degree of the dehydration (P> 0.05) .The ALT were back to normal range when diarrhea stopped.Conclusions liver is one of the involved organs when extra - gastrointestinal infection by rovavirus happens.