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膀胱内灌注血卟啉衍生物加抗坏血酸全膀胱激光照射预防膀胱癌复发
引用本文:李长岭,陈煜清,王庆,寿建忠,肖泽均,田军,王栋,宋序彦,许秉责. 膀胱内灌注血卟啉衍生物加抗坏血酸全膀胱激光照射预防膀胱癌复发[J]. 中华肿瘤杂志, 1997, 0(6)
作者姓名:李长岭  陈煜清  王庆  寿建忠  肖泽均  田军  王栋  宋序彦  许秉责
作者单位:中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院
摘    要:
目的探讨预防膀胱癌术后复发的新疗法,评价经膀胱内灌注血卟啉衍生物加抗坏血酸行激光全膀胱照射的光动力疗法预防复发的疗效。方法采用经膀胱内灌注血卟啉衍生物癌光啉(PsD-007)加抗坏血酸行全膀胱激光照射方法,治疗30例膀胱癌术后患者。结果30例患者随诊30个月,其肿瘤复发率为23.3%(7/30)。无一例发生膀胱挛缩以及皮肤光毒副反应。结论用膀胱内灌注血卟啉衍生物加抗坏血酸全膀胱照射能有效地预防膀胱癌的复发。在治疗过程中,受治患者无需避光护理,为治疗提供了方便。

关 键 词:膀胱肿瘤  血卟啉衍生物  抗坏血酸  光动力疗法

Whole bladder wall laser irradiation to prevent bladder cancer recurrence with intravesical HpD and ascorbic acid
Li Changling,Chen Yuqing,Wang Qing,et al.. Whole bladder wall laser irradiation to prevent bladder cancer recurrence with intravesical HpD and ascorbic acid[J]. Chinese Journal of Oncology, 1997, 0(6)
Authors:Li Changling  Chen Yuqing  Wang Qing  et al.
Abstract:
Objective To evaluate the effect of whole bladder wall laser irradiation with intravesical HpD and ascorbic acid on bladder cancer recurrence. Methods Photodynamic therapy(PDT) was performed by intravesical instillation of hematoporphyrin derivative (HpD) PsD 007 containing ascorbic acid followed by whole bladder wall laser irradiation in 30 post operative cases of bladder cancer. Results The tumour recurrence rate was 23.3% (7/30) on follow up for 30 months after PDT. No photo sensitizing effects was found on the skin of patients, nor was retraction of bladder observed in any case of this series. Conclusion This method is effective in the prevention of bladder cancer recurrence. Protection from light is not necessary during treatment.
Keywords:Bladder neoplasm Hematoporphyrin derivative Ascorbic acid Photodynamic therapy
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