| 抗乳腺小叶增生合剂的质量标准研究 |
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| 引用本文： | 王亚洲,吕建伟. 抗乳腺小叶增生合剂的质量标准研究[J]. 中国药房, 2012, 0(23): 2165-2167 |
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| 作者姓名： | 王亚洲 吕建伟 |
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| 作者单位： | [1]广西医科大学第四附属医院,广西柳州545005 [2]广西柳州市中医院,广西柳州545001 |
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| 摘 要： | 目的:建立抗乳腺小叶增生合剂的质量标准。方法:采用薄层色谱(TLC)法对处方中的白芍、当归和丹参进行定性鉴别;采用高效液相色谱法对芍药苷、阿魏酸和甘草酸进行含量测定。结果:TLC特征斑点明显、专属性强。芍药苷、阿魏酸和甘草酸的检测浓度分别在25.96～259.65、2.15～21.55、31.63～316.30μg.mL-1范围内与各自峰面积积分值呈良好线性关系(r分别为0.9995、0.9998、0.9996);平均加样回收率分别为100.82%、98.61%和100.39%,RSD分别为2.64%、2.43%和2.98%(n均为6)。结论:所建标准可用于抗乳腺小叶增生合剂的质量控制。
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| 关 键 词： | 抗乳腺小叶增生合剂 芍药苷 阿魏酸 甘草酸 高效液相色谱法 薄层色谱法 质量标准 |
Quality Standard of Anti-lobular Hypertrophy Mixture |
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| Affiliation: | WANG Ya-zhou(The Forth Affiliated Hospital of Guangxi Medical University, Guangxi Liuzhou 545005, China) LU Jian-wei(Liuzhou Traditional Chinese Medicine Hospital, Guangxi Liuzhou 545001, China) |
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| Abstract: | OBJECTIVE： To establish a quality standard of Anti-lobular hypertrophy mixture. METHODS：Paeonia lactiflora, Angelica sinensis and Salvia miltiorrhiza in the formula were identified qualitatively by TLC. The contents of paeoniflorin, ferulic acid and glycyrrhizic acid were determined by HPLC. RESULTS： The TLC spots were clear and specific. The linear ranges for paeoniflorin, ferulic acid and glycyrrhizic acid were 25.96-259.65 μg. mL- t （r= 0.999 5）, 2.15-21.55 μg mL- 1 （r： 0.999 8） and 31.63-316.30 μg.mL-1 （r=0.999 6） respectively. The average recoveries were 100.82%, 98.61% and 100.39% ,RSD were 2.64% - 2.43 % and 2.98% （n=6）. CONCLUSION： The established standard can be used for the quality control of Anti-lobular hypertrophy mixture. |
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| Keywords: | Anti-lobular hypertrophy mixture Paeoniflorin Ferulic acid Glycyrrhizic acid HPLC TLC Quality standard |
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