Total and Regional Body Volumes Derived From Dual-Energy X-Ray Absorptiometry Output |
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| Authors: | Joseph P. Wilson Bo Fan John A. Shepherd |
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| Affiliation: | 1. University of California Berkeley–UCSF Graduate Program in Bioengineering, San Francisco, CA, USA;2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA;1. Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine & Allied Sciences, Timarpur, New Delhi 110054, India;2. Department of Endocrinology and Metabolism, Army Hospital (Research & Referral), Delhi Cantonment, New Delhi, India;3. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India;4. Department of Medicine, B. R. Sur Institute of Homeopathy, New Delhi, India;1. Division of Clinical Immunology and Rheumatology, Department of Medicine, UAB Osteoporosis Prevention and Treatment Clinic, University of Alabama at Birmingham, Birmingham, AL, USA;2. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;3. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and Endocrinology and Metabolism Institute, Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH, USA;1. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, Milano, Italy;2. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy;3. Servizio di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese, Italy;4. Servizio di Fisica Sanitaria, Fondazione IRCCS Ca'' Granda - Ospedale Maggiore Policlinico, Milano, Italy;5. Mineralometria Ossea Computerizzata e Ambulatorio Malattie Metabolismo Minerale e Osseo, Servizio di Medicina Nucleare, Fondazione IRCCS Ca'' Granda - Ospedale Maggiore Policlinico, Milano, Italy;1. Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Bedford Park, Australia;2. North West Academic Centre, The University of Melbourne, St Albans, Australia;3. Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, IL, USA;4. Department of Mechanical Engineering, University of Melbourne, Parkville, Australia |
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| Abstract: | ![]()
Total body volume is an important health metric used to measure body density, shape, and multicompartmental body composition but is currently only available through underwater weighing or air displacement plethysmography (ADP). The objective of this investigation was to derive an accurate body volume from dual-energy X-ray absorptiometry (DXA)–reported measures for advanced body composition models. Volunteers received a whole body DXA scan and an ADP measure at baseline (N = 25) and 6 mo (N = 22). Baseline measures were used to calibrate body volume from the reported DXA masses of fat, lean, and bone mineral content. A second population (N = 385) from the National Health and Nutrition Examination Survey was used to estimate the test-retest precision of regional (arms, legs, head, and trunk) and total body volumes. Overall, we found that DXA-volume was highly correlated to ADP-volume (R2 = 0.99). The 6-mo change in total DXA-volume was highly correlated to change in ADP-volume (R2 = 0.98). The root mean square percent coefficient of variation precision of DXA-volume measures ranged from 1.1% (total) to 3.2% (head). We conclude that the DXA-volume method can measure body volume accurately and precisely, can be used in body composition models, could be an independent health indicator, and is useful as a prospective or retrospective biomarker of body composition. |
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