母乳喂养与儿童孤独症关系的Meta分析

目的 分析母乳喂养与儿童孤独症的关系,为孤独症防治提供理论依据。方法 运用Revman 5.3软件,对发表于2006-2017年有关母乳喂养与儿童孤独症关系的病例对照研究进行Meta分析,根据异质性检验结果选择固定效应模型或随机效应模型,计算OR值及95%CI,评估发表偏倚,进行敏感性分析,并对母乳喂养时间按照>1月、>3月、>6月、>12月进行亚组分析。结果 最终选出11篇文献13项研究,累计病例2 323例,对照2 839例。合并效应量结果显示,母乳喂养与孤独症关系的OR值及95%CI为0.49(0.35~0.68) (P＜0.05);亚组分析结果显示,母乳喂养>3月的合并OR值及95%CI为0.66(0.49~0.91)(P＜0.05),母乳喂养>6月的合并OR值及95%CI为0.40 (0.32~0.49)(P＜0.05)。结论 母乳喂养可能是儿童孤独症的保护因素,应提倡母乳喂养至6个月以上。

Meta-analysis on the association between breastfeeding and childhood autism

Objective To analyze the association between breastfeeding and childhood autism,in order to provide theoretical basis for the prevention and treatment of autism. Methods Case-control studies on the association between breastfeeding and childhood autism from 2006 to 2017 were analyzed by Meta-analysis with Revman5.3 software.The fixed effect model or random effect model were selected by the heterogeneity test results.The OR value and 95%CI were calculated,publication bias and sensitivity analysis were conducted.Subgroup analysis was conducted according to the breastfeeding duration time (>1 m,>3 m,>6 m,>12 m). Results Totally 11 published articles (13 studies) were selected,including 2 323 cases and 2 839 control cases.The OR and 95%CI of breastfeeding associated with autism were 0.49(0.35~0.68)] (P＜0.05); Subgroup analysis revealed that the values of OR and 95%CI of breastfeeding duration >3 months and >6 months were 0.66(0.49~0.91)] and 0.40(0.32~0.49)](both P＜0.05),respectively. Conclusion Breastfeeding may be a protective factor for childhood autism.So breastfeeding at least for 6 months is suggested to be promoted.