| 扩张型心肌病大鼠心功能减弱与SlRTl表达下调有关 |
| |
| 引用本文： | 刘杜,周乾毅,李小晶,张淑娟,朱磊,赵运海,袁新初,袁琼.扩张型心肌病大鼠心功能减弱与SlRTl表达下调有关[J].中国医药指南,2013(25):53-54. |
| |
| 作者姓名： | 刘杜 周乾毅 李小晶 张淑娟 朱磊 赵运海 袁新初 袁琼 |
| |
| 作者单位： | [1]武汉科技大学医学院药学系,湖北武汉430081 [2]武汉科技大学医学院组织胚胎学教研室,湖北武汉430081 [3]武汉科技大学天佑医院超声影像科,湖北武汉430000 |
| |
| 摘 要： | 目的探讨SIRT1在扩张型心肌病（DCM）大鼠心肌中的表达及其意义。方法采用腹腔注射阿霉素8周建立大鼠DCM模型，彩色多普勒检测大鼠左心室结构和功能，采用免疫组织化学方法及Western blot技术检测心肌组织中SIRT1蛋白表达水平。结果与正常组相比，DCM组大鼠左室舒张期末径和左室收缩期末径均明显增大，左室射血分数明显下降；DCM大鼠心肌组织中SIRT1蛋白表达水平明显下调。结论 SIRT1在DCM心肌中表达下调，提示其与DCM的发生与发展相关。
|
| 关 键 词： | 扩张型心肌病 SIRTl |
Involvement of SIRT1 Expression in Heart Dysfunction from Dilated Cardiomyopathy Rat |
| |
| LIU Du,ZHOU Qian-yi,L,Xiao-jing,ZHANG Shu-juan,ZHU Lei,ZHAO Yun-hai,YUAN Xin-chu,YUAN Qiong.Involvement of SIRT1 Expression in Heart Dysfunction from Dilated Cardiomyopathy Rat[J].Guide of China Medicine,2013(25):53-54. |
| |
| Authors: | LIU Du ZHOU Qian-yi L Xiao-jing ZHANG Shu-juan ZHU Lei ZHAO Yun-hai YUAN Xin-chu YUAN Qiong |
| |
| Institution: | 1 Department of Pharmacology, College of Pharmacy, Wuhan University Science and Technology, Wuhan 430081, China; 2 Department of Histology and Embryology, Wuhan University Science and Technology, Wuhan 430081, China; 3 Department of Ultrasonic lmaging, Tianyou Hospital, Wuhan University Science and Technology, Wuhan 430000, China) |
| |
| Abstract: | Objective To demenstrate the relationship of SIRT1 expression and heart dysfunction from dilated cardiomyopathy （DCM） rat.Methods The rat model of DCM was established by intraperitoneal injection of adriamycin once a week for 8 weeks. Left ventricular end diastolic diameter,1eft ventricular end systolic diameter and left ventricular ejection fraction were measured by Doppler. The expression of SIRT1 was detected with immunohistochemistry and Western Blotting,respectively.Results Compared with the normal rats,both the LVDD and LVDS were increased and the LVEF decreased.The expression of SIRT1 was down-regulated significantly in the rats with DCM.Conclusion The expression of SIRT1 downregulation in the cardiomyocytes may be associated with the progression and pathogenesis of DCM. |
| |
| Keywords: | Dilated cardiomyopathy SIRT1 |
| 本文献已被 维普 等数据库收录！ |
|
