乳腺癌病人生活质量及其影响因素现况调查

目的：了解乳腺癌病人的生活质量水平及其影响因素。方法：采用横断面研究设计,对上海3家综合性医院325例治疗期间的乳腺癌病人进行问卷调查。自行设计的一般资料问卷,欧洲癌症治疗研究组织针对肿瘤病人制定的生活质量核心问卷（EORTCQLQ-C30）及乳腺癌的特异性量表（EORTC-BR23）。结果：乳腺癌病人整体生活质量得分为（61.30±18.56）分,与EORTC提供的乳腺癌参考值比较无统计学差异（P〉0.05）,但国内、外病人在不同的生活质量子量表比较中仍存在一定差异。不同月收入组（P=0.030）和不同年龄组的乳腺癌病人间生活质量存在差异（P=0.038）;不同治疗方案组病人在躯体功能（P〈0.001）、社会功能（P=0.019）及恶心、呕吐、气促、经济困难、体形、系统治疗不良反应、手臂症状、脱发引起的烦恼这些症状比较上,差异有统计学意义;改良根治术与保乳术病人在体形得分上有显著差异（P〈0.001）。结论：乳腺癌病人的生活质量处于中等水平,影响其生活质量的主要因素有经济收入、年龄、治疗方案及具体的手术方式等。

The status and the influencing ractors of quality of life in breast cancer patients

Objective To investigate the breast cancer patients＇quality of life and the influencing factors.Methods By transversal surveillance research,325 breast cancer patients from 3 Shanghai comprehensive hospitals were asked to complete our questionnaires,the Chinese version of Cancer core quality of life questionnaire（EORTC QLQ-C30）,and breast cancer-specific quality of life questionnaire（EORTC BR23） designed by the European Organisition for research and treatment cancer.Results The score of overall quality of life is 61.30±18.56,not statistical significant different from the reference index of EORTC.But they are different in the sub-analysis of quality of life;there exists difference in the quality of life between patients from different income and age groups（P=0.030,P=0.038）.There is statistical significant difference in physical functioning（P0.001）,cognitive functioning（P=0.019） and symptoms subscale scores（including nausea and vomiting,dyspnoea,financial difficulties,body imaging,systemic therapy,arm symptoms and hair loss） between the patients undergoing different modes of treatment.And there is also statistical difference in the figure score between the patients undergoing modified radical mastectomy and breast conservative surgery.Conclusions The quality of life of breast cancer patients in this study are moderate.Difference in economic status,age,treatment therapy and surgery significantly influences the quality of life of the patients.