脑益嗪对实验性脑血栓形成及血小板聚集的抑制作用

本文报道脑益嗪对大鼠实验性脑血栓形成及兔血小板聚集的抑制作用。经大鼠颈动脉顺行注射复合血栓诱导剂造成脑血栓模型,测定伊文思兰通过血脑屏障渗入脑实质的量以反映脑血栓的严重程度。结果表明脑益嗪(67 mg/kg,灌胃)有抗脑血栓形成的作用。半体内实验表明脑益嗪(34 mg/kg,灌胃)可抑制兔血小板聚集。

EFFECTS OF CINNARIZINE ON RABBIT PLATELET AGGREGATION AND EXPERIMENTAL CEREBRAL THROMBOSIS IN RATS

A co-thrombus inducer, a mixture of ADP, thrombin and epinephrine, was injected into rat carotid artery to induce cerebral thrombosis. Evans blue was used as an indicator to reveal the blood brain barrier (BBB) permeability. The concentrations of the dye in both the infarct hemisphere and the control hemisphere were determined by spectrophotometry. The effect of cinnarizine on rabbit platelet aggregation was also studied. It was shown that cinnarizine at the dosage of 67 mg/kg and 34 mg/kg inhibited the experimental cerebral thrombosis and the AA and ADP induced platelet aggregation, respectively. These results seem to indicate that this simple model may be used as an effective method to screen anticerebrothrombotic drugs.