七氟醚安氟醚对犬单肺通气期间肺分流与氧供及氧耗的影响

目的 观察犬单肺通气时，不同浓度七氟醚，安氟醚对Ｑｓ／Ｑｔ和氧供及氧耗等氧合指标的影响。方法 １４只健康杂种犬，诱导后插入双腔气管内导管，股动静脉分别置管监测血气和各自压力。随机分为两组，Ａ组吸入０．５ＭＡＣ、１．０ＭＡＣ安氟醚，待完全排除后再顺序吸入七氟醚；Ｂ组反之，各时相均分为双肺通气（ＴＬＶ）和单肺通气（ＯＬＶ）阶段，分别于ＴＬＶ、ＯＬＶ１５分钟后测量ＱＱｔ及氧供（ＤＯ２）、氧耗（ＶＯ２）等

Effects of sevoflurane,enflurane on oxygen delivery,consumption and pulmonary shunt during one-lung ventilation in dogs

Objective To evaluate the effects of sevoflurane,enflurane on oxygen delivery,consumption and pulmonary shunt during one-lung ventilation in dogs.Methods Fourteen healthy dogs were used in this study.Following induction and double lumen endotracheal tubes placement,Various catheters were inserted into bilateral femoral arteries and veins for pressures and blood gases monitoring.All subjects were divided into two groups randomly.In group A,0 5,1 0 MAC enflurane(ENF) were given in turn firstly,then this course was repeated with sevoflurane(SEVO) after former drug had been fully eliminated;In group B,the sequence was exactly opposite.Each phase was subdivided into two ones:two-lung ventilation(TLV) and one-lung ventilation(OLV).In every phase,indexes were measured 15 minutes after TLV and OLV,respectively.All data were analyzed according to Cross-Over design rule.Results The results between A and B groups were similar when the same drug was inhaled at different time.Accompanied with the increase of inhaled concentration,systemic and pulmonary circulation indexes were depressed similarly in dose-dependent way by these two drugs.Both PaO 2 and oxygen delivery(DO 2) decreased gradually,oxygen extraction ratio(ERO 2) increased,but there was no signs of DO 2/VO 2 and anaerobic metabolism.Pulmonary shunt(Qs/Qt) showed a dose-dependent increase during TLV and OLV,the values during OLV were greater than TLV( P <0 01);though having no difference during TLV between two inhaled drugs( P <0 05),Qs/Qt was found higher when ENF was received than SEVO did at two concentration during OLV( P <0 01).Conclusion ENF and SEVO can be safely used during OLV at clinical concentration,and SEVO is more superior. [