儿科金黄色葡萄球菌感染的耐药性分析

目的对笔者所在医院儿科分离的金黄色葡萄球菌进行耐药性分析,为临床合理使用抗菌药物提供依据。方法回顾性分析笔者所在医院儿科分离的233株SAU标本来源及临床科室分布情况,并进行耐药性分析;采用VITEK-2COMPART仪器进行药敏试验,苯唑西林筛选出耐甲氧西林金黄色葡萄球菌。结果 233株SAU在痰标本及儿科重症监护室检出比例最大,分别为68.67%和31.33%;共检出MRSA40株,其检出率17.17%;在SAU中利奈唑烷、利福平、莫西沙星、喹奴普汀/达福普汀和万古霉素耐药率均为0;MRSA对红霉素、氯洁霉素、四环素、环丙沙星的耐药率显著高于甲氧西林敏感金黄色葡萄球菌,差异有统计学意义(P<0.05)。结论临床在确诊SAU感染时,应区别对待MSSA和MRSA,及时、合理使用抗生素预防和控制感染。

Analysis of drug-resistence of Staphyloccocus aureus infection in paediatrics

Objective To analyze the drug-resistance of Staphyloccocus aureus infection in authors' hospital pediatrics and provide evidence for clinically reasonable use of antibiotics. Methods Investigate to analyze the specimen source and the clinical distribution of 233 SAU strains; BioMerieux VITEK-2 COMPART was used to identify isolating strains and performe antibiotic susceptibility testing, Methicillin- resistant S.aureus was sreened by resistant oxacillin. Results The proportion of the sputum specimens and the PICU department are the highest ;Isolating rate of MRSA was 17.17%; linezolid, rifabutin, moxifloxacin, quinupristin/dalfopristin and vancomycin in SAU were no drug resistance.;Diffence in drug-resistant rate of erythromycin, clindamycin, tetracycline, ciprofloxacin between MRSA and methicillin-sensitive S.aureus is statistically significant (P < 0.05), and MRSA group is much higher drug-resistant rate. Conclusion When diagnosing infection from SAU and making a difference between MSSA and MRSA,we should use the antibiotics timely and reasonably to the prevention and control of infection.