子宫腺肌病组织中ER、PR和EGFR的表达及其临床意义

目的探讨雌激素受体、孕激素受体、表皮生长因子受体在子宫腺肌病组织中的表达情况以及ER、PR、EGFR与AM发病的关系。方法采用免疫组化SP法检测40例子宫腺肌病患者异位内膜、在位内膜及40例正常子宫内膜组织中ER、PR、EGFR的表达。结果腺肌病组异位内膜、在位内膜组织中ER、PR表达水平显著低于正常子宫内膜,异位内膜组织中ER、PR表达无周期性变化,而在位内膜和正常子宫内膜组织中ER、PR表达均符合增生期高于分泌期的变化规律。腺肌病组异位内膜、在位内膜组织中EGFR的表达水平显著高于正常子宫内膜,并且在位内膜组织中EGFR的表达水平显著高于异位内膜。结论子宫腺肌病患者异位内膜组织中ER、PR的表达水平低,可能是其对抗激素药物治疗反应差的原因。子宫腺肌病患者异位内膜、在位内膜组织中EGFR表达水平增强,提示EGFR在子宫腺肌病的发生发展中起着重要作用,可能为靶向生物治疗提供一个新的靶点。

Expression of ER,PR and EGFR in adenomyosis and its clinical significance

Objective To study estrogen receptor,progesterone receptor,epidermal growth factor receptor in the adenomyosis expression,as well as ER,PR,EGFR and AM pathogenesis.Methods Immunohistochemical SP method was used to detect 40 cases of patients with adenomyosis endometriosis,ectopic endometrium and 40 cases of normal endometrial tissue in ER,PR and EGFR expression.Results In ectopic endometrium of adenomyosis group,ectopic endometrial tissue in ER,PR expression level was significantly lower than that in normal endometrium,ectopic endometrial tissue in ER,PR expression without periodic change,and ectopic endometrium and normal endometrial tissue ER,PR expression were consistent with the proliferative phase than in the secretory phase.Ectopic endometrium of adenomyosis group,ectopic endometrial tissue in the expression level of EGFR was significantly higher than that in normal endometrium and ectopic endometrium tissues,the expression level of EGFR was significantly higher than that in ectopic endometrium.Conclusion In those Patients with adenomyosis of ectopic endometrial tissue ER,PR is expressed at low levels,which may be against hormone response to drug therapy causes differential.In those patients with adenomyosis,the expression level of EGFR in EGFR were enhanced,prompting in adenomyosis occurrence development EGFR plays an important role for targeted biological therapy,which may provide a new target point.