去氧孕烯炔雌醇治疗绝经过渡期功能失调性子宫出血临床观察

目的观察绝经过渡期去氧孕烯炔雌醇对功能失调性子宫出血的临床效果。方法选取笔者所在医院2010年2月～2012年2月166例绝经过渡期功能失调性子宫出血的临床资料,随机分为观察组(85例)和对照组(81例),观察组应用去氧孕烯炔雌醇,对照组应用米非司酮;观察用药后两者的治疗时间和体内促绒毛膜性腺激素、雌激素和黄体生成素的变化情况。结果观察组患者治疗前后促绒毛膜性腺激素FSH平均值之间差异有统计学意义(P<0.05),而黄体生成素LH和雌激素E2浓度无明显改变。比较发现,对照组患者的FSH、LH、E2在治疗前后均无显著变化。结论去氧孕烯炔雌醇对于治疗围绝经期内功能失调性子宫出血疗效肯定,止血迅速,作用无反复,值得临床推广。

Clinical observation of desogestrel and ethinylestradiol in treatment of dysfunctional uterine bleeding in menopausal transition period

Objective To observe the clinical effect of desogestrel and ethinylestradiol in the treatment of dysfunctional uterine bleeding in menopausal transition period.Methods Clinical data of 166 patients with dysfunctional uterine bleeding in menopausal transition period of treated in our hospital from February 2010 to February 2012 were selected an randomly divided into the observation group(85 patients) and the control group(81 patients).The observation group received desogestrel and ethinylestradiol while the control group received mifepristone.The treatment time and the changes of human chorionic gonadotropin,estrogen and luteinizing hormone(LH) of both groups after medication were observed.Results In the observation group,the mean values of chorionic gonadotropin FSH before and after the treatment were statistically different(P<0.05),but LH and estrogen E2 did not change significantly.After comparison,it was found that none of FSH,LH and E2 of the control group changed significantly after the treatment.Conclusion Desogestrel and ethinylestradiol is effective,fast and free of relapse in the treatment of dysfunctional uterine bleeding in menopausal transition period,thereby worthy of clinical promotion.