贝那普利联合氯沙坦对高血压靶器管的保护作用

目的:观察贝那普利与氯沙坦联合治疗对保护老年高血压病靶器管损害的优点。方法:选择1-2级老年高血压病患者180例,分为3组各60例,A组口服贝那普利片10mg,B组给予氯沙坦片50mg,C组2种药联合应用,均每天1次。结果:治疗1年后3组患者平均血压、空腹血糖、总胆固醇、血尿素氮、肌苷及醛固酮水平比较均差异无显著性意义。左室质量指数及颈动脉内膜中层厚度,C组明显低于A、B组(P<0.05或0.01);A、B2组比较无差别。血尿酸和尿β2微球蛋白水平,B、C组均低于A组(P<0.05或0.01)。血管紧张素Ⅱ水平,A组

Target Organ Protection by Benazepril plus losartan in the Treatment of Elderly Patients with Hypertension

Objective:To explore the advantages of combined treatment of Benalapril plus Lorsartan for target organ protection in elderly patients.Methods:Three groups of elderly patients with grade 1-2 hypertension were treated with Benalapril(group B),Lorsartan(group L),and Benalapril plus Lorsartan(group C) for 1 year,respectively.The differences in the following indicators among three groups were investigated:mean blood pressure(MBP),left ventricle mass index(LVMI),intima-media thickness(IMT) of cervical arteries,fast blood glucose(FBG),serum lipids,renal function,serum uric acid(SUA),plasma angiotensin II(Ang II) and aldosterone,urine 2-microalbumin(2-MG).Results:After antihypertension intervention,no significant difference was observed in MBP,FBG,total cholesterol,blood urine nitrogen(BUN),creatinine and aldosterone among groups.LVMI and IMT in group C were dramatically lower than those in groups A and B,but there was no significant difference between groups B and L.SUA and 2-MG in group B was higher than those in group L and C.There was significant difference in the levels of Ang II among three groups,the highest in group B,medium in group C and the lowest in group L.Conclusion:Combined use of Benalapril and Lorsartan can prevent the target organ from damage by multiple mechanisms in the elderly patients with hypertension and its effect is superior to that used alone.