59例多发性硬化患者不同中医证型的免疫学研究

目的 观察多发性硬化患者不同中医证型的免疫学功能差异。方法 对59例多发性硬化急性期患者的临床表现进行辨证分为肝肾阴虚型（40例）及阴阳两虚型（19例），并比较两证型患者之间发病年龄、复发次数、病程长短、核磁共振、诱发电位以及免疫学差异。结果 阴阳两虚型患者发病年龄显著晚于肝肾阴虚型（P〈0．01）；阴阳两虚型患者（12例）脑脊液白蛋白水平高于肝肾阴虚型患者（26例，P〈0．05）；肝肾阴虚型患者的发病次数和阴阳两虚型的脑脊液髓鞘碱性蛋白、血脑屏障指数有升高趋势（P值分别为0、056，0．074，0．093）。结论 多发性硬化患者肝肾阴虚型与阴阳两虚型两型之间可能存在免疫学差异.

Study on Immunological Pathogenesis of 59 Patients with Multiple Sclerosis of Different TCM Syndrome Types

Objective To explore the immunological pathogenesis of multiple sclerosis(MS)patients of different TCM syndrome types.Methods Fifty-nine MS patients were assigned to two types by syndrome typing according to their clinical manifestations,the Gan-Shen yin-deficiency(GSYD,40 cases)type and the both yin-yang deficiency(YYD,19 cases)type.Difference of patients' age of first attack,times of relapsing,duration of disease,MRI finding and evoked potential between the two groups were compared.The immunology indexes were also compared in part of the patients(26 cases in GSYD type and 12 cases in YYD type).Results The age of first attack was later(P<0.01),level of myelin basic protein in cerebrospinal fluid was higher(P<0.05),in the YYD type than those in the GSYD type.Besides,the relapsing time in GSYD type,and the blood-brain barrier index and level of myelin basic protein in YYD type showed an ascending trend(P = 0.056,0.074,0.093,respectively).Conclusion Immunological difference exists between the MS patients of GSYD type and those of YYD type.