沙培林治疗恶性胸腔积液的应用探讨

目的观察沙培林治疗恶性胸腔积液的临床疗效及不良反应。方法对不愿意作全身放、化疗的晚期恶性肿瘤并胸积液患者44例随机分成两组,甲组为沙培林治疗组,乙组为顺氯胺铂对照组。经B超定位并行胸腔穿刺术或胸腔闭式引流术,抽取胸腔积液后胸腔内给药治疗。结果甲组完全缓解9例,部分缓解11例,总有效率为90.91%;乙组完全缓解5例,部分缓解9例,总有效率为63.64%。经统计学分析,两者差异具有显著性(P<0.05)。副作用:甲组以发热为主,而乙组则胃肠道反应及白细胞降低较多。结论胸腔注入沙培林治疗恶性胸腔积液疗效好,不良反应少。

Application of Sapylin (OK-432) in the Treatment of Malignant Pleural Effusion

Objective To study the clinical and adverse effects of sapylin on malignant pleural effusion. Methods 44 patients with malignant pleural effusion refused radiotherapy and chemotherapy were randomly divided into sapylin group and cisplatin group. All patients accepted sapylin or cisplatin treatment by intrapleural injection after thoracentesis or thoracic drainage directed by B-ultrasound. Results The complete response (CR) and partial response (PR) in sapalin group was 9 cases and 11 cases, respectively, with the total effective rate of 90.91%. The complete response(CR) and partial response (PR) in cispktin group was S cases and 9 cases, respectively, with the total effective rate of 63.64%. The difference between two groups was significant. Fever was the major side effect of sapylin, while gastrointestinal reaction and white blood cell decline were the main side effects of cisplatin. Conclusion The effect of sapylin on malignant pleural effusion is remarkable and with fewer adverse reaction.